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dc.contributor.authorByeon, Seong Rim-
dc.contributor.authorKim, Hyunjin Vincent-
dc.contributor.authorJeon, Mijin-
dc.contributor.authorAhn, Young Gil-
dc.contributor.authorKim, Maeng Sup-
dc.contributor.authorKong, Jae Yang-
dc.contributor.authorKim, Hye Yun-
dc.contributor.authorKim, Young Soo-
dc.contributor.authorKim, Dong Jin-
dc.date.accessioned2024-01-20T12:04:07Z-
dc.date.available2024-01-20T12:04:07Z-
dc.date.created2022-01-10-
dc.date.issued2013-06-01-
dc.identifier.issn0960-894X-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/127976-
dc.description.abstractAlzheimer's disease drug discovery regarding exploration into the molecules and processes has focused on the intrinsic causes of the brain disorder correlated with the accumulation of amyloid-beta. An anti-amyloidogenic bis-styrylbenzene derivative, KMS80013, showed excellent oral bioavailability (F = 46.2%), facilitated brain penetration (26%, iv) in mouse and target specific in vivo efficacy in acute AD mouse model attenuating the cognitive deficiency in Y-maze test. Acute toxicity (LD50 > 2000 mg/kg) and hERG channel inhibition (14% at 10 mu M) results indicated safety of KMS80013. (C) 2013 Elsevier Ltd. All rights reserved.-
dc.languageEnglish-
dc.publisherPergamon Press Ltd.-
dc.subjectSOLID-PHASE SYNTHESIS-
dc.subjectCURCUMIN-
dc.subjectDRUG-
dc.subjectHYPOTHESIS-
dc.subjectPATHOLOGY-
dc.subjectPEPTIDE-
dc.titleTherapeutic and pharmacokinetic characterizations of an anti-amyloidogenic bis-styrylbenzene derivative for Alzheimer's disease treatment-
dc.typeArticle-
dc.identifier.doi10.1016/j.bmcl.2013.02.104-
dc.description.journalClass1-
dc.identifier.bibliographicCitationBioorganic & Medicinal Chemistry Letters, v.23, no.11, pp.3467 - 3469-
dc.citation.titleBioorganic & Medicinal Chemistry Letters-
dc.citation.volume23-
dc.citation.number11-
dc.citation.startPage3467-
dc.citation.endPage3469-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.identifier.wosid000318976100070-
dc.identifier.scopusid2-s2.0-84877586188-
dc.relation.journalWebOfScienceCategoryChemistry, Medicinal-
dc.relation.journalWebOfScienceCategoryChemistry, Organic-
dc.relation.journalResearchAreaPharmacology & Pharmacy-
dc.relation.journalResearchAreaChemistry-
dc.type.docTypeArticle-
dc.subject.keywordPlusSOLID-PHASE SYNTHESIS-
dc.subject.keywordPlusCURCUMIN-
dc.subject.keywordPlusDRUG-
dc.subject.keywordPlusHYPOTHESIS-
dc.subject.keywordPlusPATHOLOGY-
dc.subject.keywordPlusPEPTIDE-
dc.subject.keywordAuthorAmyloid-beta-
dc.subject.keywordAuthorAlzheimer&apos-
dc.subject.keywordAuthors disease-
dc.subject.keywordAuthorAggregation inhibitor-
dc.subject.keywordAuthorPharmacokinetics-
dc.subject.keywordAuthorBehavior test-
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