DSpace at KISTKIST Article2013

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dc.contributor.authorPark, Jung-eun-
dc.contributor.authorJi, Wan Keun-
dc.contributor.authorJang, Jae Wan-
dc.contributor.authorPae, Ae Nim-
dc.contributor.authorChoi, Keehyun-
dc.contributor.authorChoi, Ki Hang-
dc.contributor.authorKang, Jahyo-
dc.contributor.authorRoh, Eun Joo-
dc.date.accessioned2024-01-20T12:34:27Z-
dc.date.available2024-01-20T12:34:27Z-
dc.date.created2021-09-01-
dc.date.issued2013-03-15-
dc.identifier.issn0960-894X-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/128247-
dc.description.abstractTo obtain selective and potent inhibitor for T-type calcium channel by ligand based drug design, 2-hydroxy-3-phenoxypropyl piperazine derivatives were synthesized and evaluated for in vitro activities. Compound 6m and 6q showed high selectivity over hERG channel (IC50 ratio of hERG/alpha(1G) 6m = 8.5, 6q = 18.38) and they were subjected to measure pharmacokinetics profiles. Among them compound 6m showed an excellent pharmacokinetic profile in rats. (C) 2013 Elsevier Ltd. All rights reserved.-
dc.languageEnglish-
dc.publisherPergamon Press Ltd.-
dc.subjectCA2+ CHANNELS-
dc.subjectINHIBITION-
dc.subjectTARGETS-
dc.titleSynthesis and biological evaluation of 1-(2-hydroxy-3-phenyloxypropyl)piperazine derivatives as T-type calcium channel blockers-
dc.typeArticle-
dc.identifier.doi10.1016/j.bmcl.2012.12.072-
dc.description.journalClass1-
dc.identifier.bibliographicCitationBioorganic & Medicinal Chemistry Letters, v.23, no.6, pp.1887 - 1890-
dc.citation.titleBioorganic & Medicinal Chemistry Letters-
dc.citation.volume23-
dc.citation.number6-
dc.citation.startPage1887-
dc.citation.endPage1890-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.identifier.wosid000315331500065-
dc.identifier.scopusid2-s2.0-84874654558-
dc.relation.journalWebOfScienceCategoryChemistry, Medicinal-
dc.relation.journalWebOfScienceCategoryChemistry, Organic-
dc.relation.journalResearchAreaPharmacology & Pharmacy-
dc.relation.journalResearchAreaChemistry-
dc.type.docTypeArticle-
dc.subject.keywordPlusCA2+ CHANNELS-
dc.subject.keywordPlusINHIBITION-
dc.subject.keywordPlusTARGETS-
dc.subject.keywordAuthort-type calcium channel-
dc.subject.keywordAuthorvirtual screening-
dc.subject.keywordAuthorneuropathic pain-
dc.subject.keywordAuthorfocused library-
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