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dc.contributor.authorEl-Gamal, Mohammed I.-
dc.contributor.authorAnbar, Hanan S.-
dc.contributor.authorChung, Hye Jin-
dc.contributor.authorKim, Hyun-Il-
dc.contributor.authorCho, Young-Jin-
dc.contributor.authorLee, Bong Sang-
dc.contributor.authorLee, Sun Ahe-
dc.contributor.authorMoon, Ji Yun-
dc.contributor.authorLee, Dong Jin-
dc.contributor.authorKwon, Dow-
dc.contributor.authorChoi, Won-Jai-
dc.contributor.authorJeon, Hong-Ryeol-
dc.contributor.authorOh, Chang-Hyun-
dc.date.accessioned2024-01-20T12:34:38Z-
dc.date.available2024-01-20T12:34:38Z-
dc.date.created2022-01-10-
dc.date.issued2013-03-01-
dc.identifier.issn0960-894X-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/128254-
dc.description.abstractSynthesis of a new ester prodrug of olmesartan, olmesartan hexetil (1), is described. It is in vitro stabilities and in vivo pharmacokinetics (PK) were evaluated. It showed high stability in simulated gastric juice, and was rapidly hydrolyzed to olmesartan in rat liver microsomes and rat plasma in vitro. C-max and AUC(last) for olmesartan were significantly increased in case of hexetil prodrug, compared with olmesartan medoxomil. Olmesartan hexetil is proposed to be an efficient prodrug of olmesartan with markedly increased oral bioavailability. (C) 2013 Elsevier Ltd. All rights reserved.-
dc.languageEnglish-
dc.publisherPergamon Press Ltd.-
dc.subjectII RECEPTOR ANTAGONISTS-
dc.subjectANGIOTENSIN-CONVERTING ENZYME-
dc.subjectBIOACTIVATING HYDROLASE-
dc.subjectMEDOXOMIL-
dc.subjectBLOCKER-
dc.subjectRENIN-
dc.subjectACIDS-
dc.titleDiscovery of olmesartan hexetil: A new potential prodrug of olmesartan-
dc.typeArticle-
dc.identifier.doi10.1016/j.bmcl.2012.12.090-
dc.description.journalClass1-
dc.identifier.bibliographicCitationBioorganic & Medicinal Chemistry Letters, v.23, no.5, pp.1347 - 1350-
dc.citation.titleBioorganic & Medicinal Chemistry Letters-
dc.citation.volume23-
dc.citation.number5-
dc.citation.startPage1347-
dc.citation.endPage1350-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.identifier.wosid000314693400039-
dc.identifier.scopusid2-s2.0-84873714069-
dc.relation.journalWebOfScienceCategoryChemistry, Medicinal-
dc.relation.journalWebOfScienceCategoryChemistry, Organic-
dc.relation.journalResearchAreaPharmacology & Pharmacy-
dc.relation.journalResearchAreaChemistry-
dc.type.docTypeArticle-
dc.subject.keywordPlusII RECEPTOR ANTAGONISTS-
dc.subject.keywordPlusANGIOTENSIN-CONVERTING ENZYME-
dc.subject.keywordPlusBIOACTIVATING HYDROLASE-
dc.subject.keywordPlusMEDOXOMIL-
dc.subject.keywordPlusBLOCKER-
dc.subject.keywordPlusRENIN-
dc.subject.keywordPlusACIDS-
dc.subject.keywordAuthorAntihypertensive-
dc.subject.keywordAuthorOlmesartan medoxomil-
dc.subject.keywordAuthorOlmesartan hexetil-
dc.subject.keywordAuthorProdrug-
dc.subject.keywordAuthorEster-
dc.subject.keywordAuthorPharmacokinetics-
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