Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Park, So Young | - |
dc.contributor.author | Nho, Chu Won | - |
dc.contributor.author | Kwon, Dae Young | - |
dc.contributor.author | Kang, Young-Hee | - |
dc.contributor.author | Lee, Ki Won | - |
dc.contributor.author | Park, Jung Han Yoon | - |
dc.date.accessioned | 2024-01-20T13:03:16Z | - |
dc.date.available | 2024-01-20T13:03:16Z | - |
dc.date.created | 2021-09-01 | - |
dc.date.issued | 2013-01-28 | - |
dc.identifier.issn | 0007-1145 | - |
dc.identifier.uri | https://pubs.kist.re.kr/handle/201004/128433 | - |
dc.description.abstract | Maslinic acid is found in various natural sources, most notably in pomace olive oil, and exerts pro-apoptotic activities in various cancer cells in vitro. In the present study, DU145 human prostate cancer cells were cultured with 0-25 mM-maslinic acid to examine the effects of maslinic acid on the metastatic capacity of prostate cancer cells. Maslinic acid significantly (P < 0.05) inhibited the basal and epidermal growth factor (EGF)-induced migration (27-64 %), invasion (23-60%) and adhesion (8-40%) of DU145 cells. Maslinic acid significantly (P < 0.05) down-regulated both basal and EGF-stimulated secretion of matrix metalloproteinase (MMP)-9 (25-67 %), MMP-2 (50-86 %), urokinase-type plasminogen activator (uPA, about 100 %), vascular endothelial growth factor (VEGF, 98-100 %) and tissue inhibitors of metalloproteinases (TIMP)-1, as well as expression of uPA receptor (uPAR), intercellular adhesion molecules (22-33 %), vascular cell adhesion molecules (23-46%) and E-cadherin, whereas it increased TIMP-2 secretion. Maslinic acid dramatically reduced the levels of hypoxia-inducible factor-1 alpha (HIF-1 alpha) protein and mRNA; the reduction was accompanied by reduced stability, nuclear levels and transcriptional activity of HIF-1 alpha. The levels of phospho-Akt and phospho-extracellular signal-related kinase (ERK) were reduced in cells treated with maslinic acid, and the phosphoinositide 3-kinase inhibitor LY294002 and the mitogen-activated protein kinase kinase inhibitor PD98059 reduced HIF-1 alpha levels and VEGF secretion. The results show that maslinic acid markedly inhibited the migration, invasion and adhesion of DU145 prostate cancer cells. Suppressing HIF-1 alpha activation by inhibiting Akt and ERK activation may be part of the mechanism by which maslinic acid inhibited uPAR, E-cadherin, VEGF and MMP expression in DU145 cells. | - |
dc.language | English | - |
dc.publisher | CAMBRIDGE UNIV PRESS | - |
dc.subject | MATRIX METALLOPROTEINASES | - |
dc.subject | NATURAL TRITERPENE | - |
dc.subject | FACTOR 1-ALPHA | - |
dc.subject | TUMOR-GROWTH | - |
dc.subject | EXPRESSION | - |
dc.subject | PROLIFERATION | - |
dc.subject | ANGIOGENESIS | - |
dc.subject | PATHWAY | - |
dc.subject | HYPOXIA-INDUCIBLE-FACTOR-1-ALPHA | - |
dc.subject | HIF-1-ALPHA | - |
dc.title | Maslinic acid inhibits the metastatic capacity of DU145 human prostate cancer cells: possible mediation via hypoxia-inducible factor-1 alpha signalling | - |
dc.type | Article | - |
dc.identifier.doi | 10.1017/S0007114512000967 | - |
dc.description.journalClass | 1 | - |
dc.identifier.bibliographicCitation | BRITISH JOURNAL OF NUTRITION, v.109, no.2, pp.210 - 222 | - |
dc.citation.title | BRITISH JOURNAL OF NUTRITION | - |
dc.citation.volume | 109 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 210 | - |
dc.citation.endPage | 222 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.identifier.wosid | 000313975800003 | - |
dc.identifier.scopusid | 2-s2.0-84873045777 | - |
dc.relation.journalWebOfScienceCategory | Nutrition & Dietetics | - |
dc.relation.journalResearchArea | Nutrition & Dietetics | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | MATRIX METALLOPROTEINASES | - |
dc.subject.keywordPlus | NATURAL TRITERPENE | - |
dc.subject.keywordPlus | FACTOR 1-ALPHA | - |
dc.subject.keywordPlus | TUMOR-GROWTH | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | PROLIFERATION | - |
dc.subject.keywordPlus | ANGIOGENESIS | - |
dc.subject.keywordPlus | PATHWAY | - |
dc.subject.keywordPlus | HYPOXIA-INDUCIBLE-FACTOR-1-ALPHA | - |
dc.subject.keywordPlus | HIF-1-ALPHA | - |
dc.subject.keywordAuthor | Metastasis | - |
dc.subject.keywordAuthor | Prostate cancer cells | - |
dc.subject.keywordAuthor | Hypoxia-inducible factor-1 alpha | - |
dc.subject.keywordAuthor | Vascular endothelial growth factor | - |
dc.subject.keywordAuthor | Matrix metalloproteinase | - |
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