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dc.contributor.authorChoi, Won-Kyoung-
dc.contributor.authorEl-Gamal, Mohammed I.-
dc.contributor.authorChoi, Hong Seok-
dc.contributor.authorHong, Jun Hee-
dc.contributor.authorBaek, Daejin-
dc.contributor.authorChoi, Kihang-
dc.contributor.authorOh, Chang-Hyun-
dc.date.accessioned2024-01-20T14:02:02Z-
dc.date.available2024-01-20T14:02:02Z-
dc.date.created2022-01-10-
dc.date.issued2012-09-20-
dc.identifier.issn0253-2964-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/128864-
dc.description.abstractA series of new diarylureas and diarylamides possessing 1,3,4-triarylpyrazole scaffold was synthesized and their in vitro antiproliferative activities against A375P human melanoma cell line and NCI-60 cell line panel were tested. Compounds 9, 11, 12, 14, and 17-21 showed superior potency against A375P to Sorafenib. Over the NCI-60 cancer cell line panel, compound 14 possessing a methoxy group, amide linker, and 4-chloro-3-(trifluoromethyl)phenyl terminal ring showed the highest potency and broad-spectrum anticancer activity. Compound 13 showed high selectivity towards leukemia subpanel over other cancer types.-
dc.languageEnglish-
dc.publisherKOREAN CHEMICAL SOC-
dc.subjectMELANOMA-CELL LINE-
dc.subjectANTIPROLIFERATIVE ACTIVITY-
dc.subjectDERIVATIVES-
dc.subjectDISCOVERY-
dc.titleDesign, Synthesis, and Preliminary Cytotoxicity Evaluation of New Diarylureas and Diarylamides Possessing 1,3,4-Triarylpyrazole Scaffold-
dc.typeArticle-
dc.identifier.doi10.5012/bkcs.2012.33.9.2991-
dc.description.journalClass1-
dc.identifier.bibliographicCitationBULLETIN OF THE KOREAN CHEMICAL SOCIETY, v.33, no.9, pp.2991 - 2998-
dc.citation.titleBULLETIN OF THE KOREAN CHEMICAL SOCIETY-
dc.citation.volume33-
dc.citation.number9-
dc.citation.startPage2991-
dc.citation.endPage2998-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.description.journalRegisteredClasskci-
dc.identifier.kciidART001695312-
dc.identifier.wosid000309307400031-
dc.identifier.scopusid2-s2.0-84866406828-
dc.relation.journalWebOfScienceCategoryChemistry, Multidisciplinary-
dc.relation.journalResearchAreaChemistry-
dc.type.docTypeArticle-
dc.subject.keywordPlusMELANOMA-CELL LINE-
dc.subject.keywordPlusANTIPROLIFERATIVE ACTIVITY-
dc.subject.keywordPlusDERIVATIVES-
dc.subject.keywordPlusDISCOVERY-
dc.subject.keywordAuthorA375P-
dc.subject.keywordAuthorAnticancer-
dc.subject.keywordAuthorDiarylamide-
dc.subject.keywordAuthorDiarylurea-
dc.subject.keywordAuthor1,3,4-Triarylpyrazole-
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