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Radiosynthesis and Biodistribution of an I-125-labeled Resveratrol Derivative

Authors
Kim, Sung Kew; Lee, Woong San; Han, Sang Jin; Kim, Eun Jung; El-Gamal, Mohammed I.; Kim, Byoung Soo; Choi, Tae Hyun; Choi, Chang Woon; Ham, In-Hye; Oh, Chang-Hyun; Choi, Ho-Young; Cho, Jung-Hyuck
Issue Date
2012-02-20
Publisher
KOREAN CHEMICAL SOC
Citation
BULLETIN OF THE KOREAN CHEMICAL SOCIETY, v.33, no.2, pp.489 - 491
Abstract
An I-125-labeled resveratrol derivative 1 was synthesized. It was purified by reverse phase HPLC. Radiochemical purity of the product was more than 98%, and the yield was 35% (decay-corrected). Its biodistribution in tumor-bearing mice was studied. The results showed that the highest radioactivity was located in intestine and stomach. The biodistribution profile suggests that compound 1 can be effectively used as a promising imaging probe for intestine and stomach.
Keywords
RED WINE; TRANS-RESVERATROL; SMALL-INTESTINE; IN-VITRO; GRAPES; CELLS; POLYPHENOL; METABOLISM; ABSORPTION; RATS; RED WINE; TRANS-RESVERATROL; SMALL-INTESTINE; IN-VITRO; GRAPES; CELLS; POLYPHENOL; METABOLISM; ABSORPTION; RATS; Radiosynthesis; Resveratrol; Iodoresveratrol; Biodistribution; Imaging agent
ISSN
0253-2964
URI
https://pubs.kist.re.kr/handle/201004/129529
DOI
10.5012/bkcs.2012.33.2.489
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KIST Article > 2012
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