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Isolation of prenylated isoflavonoids from Cudrania tricuspidata fruits that inhibit A2E photooxidation

Authors
Uddin, G.M.; Lee, H.J.; Jeon, J.-S.; Chung, D.; Kim, C.Y.
Issue Date
2011-09
Citation
Natural Product Sciences, v.17, no.3, pp.206 - 211
Abstract
High-performance liquid chromatography coupled to an online ABTS +-based assay (online HPLC-ABTS +) system was used to determine the principal antioxidants in Cudrania tricuspidata fruits. Six prenylated isoflavonoids (1 - 6) were isolated from C. tricuspidata fruits according to the online HPLC-ABTS + system. The structures of isolated compounds, alpiniumisoflavone (1), 6,8-diprenylorobol (2), 6,8-diprenylgenistein (3), pomiferin (4), 4′-methylalpiniumisoflavone (5), and osajin (6) were identified by their retention time, UV spectra, ESI-MS, and NMR data. Among these compounds, 6,8-diprenylorobol (2) and pomiferin (4) reduced A2E photooxidation in a dose dependent manner.
Keywords
4' methylalpiniumisoflavone; 6,8 diprenylgenistein; 6,8 diprenylorobol; alpiniumisoflavone; antioxidant; isoflavonoid; lipofuscin; osajin; pomiferin; protein A2E; unclassified drug; antioxidant activity; article; controlled study; Cudrania tricuspidata; drug determination; drug isolation; drug retention; drug structure; electrospray mass spectrometry; fruit; high performance liquid chromatography; nonhuman; nuclear magnetic resonance spectroscopy; online system; photooxidation; prenylation; protein synthesis inhibition; structure analysis; ultraviolet spectroscopy; 4' methylalpiniumisoflavone; 6,8 diprenylgenistein; 6,8 diprenylorobol; alpiniumisoflavone; antioxidant; isoflavonoid; lipofuscin; osajin; pomiferin; protein A2E; unclassified drug; antioxidant activity; article; controlled study; Cudrania tricuspidata; drug determination; drug isolation; drug retention; drug structure; electrospray mass spectrometry; fruit; high performance liquid chromatography; nonhuman; nuclear magnetic resonance spectroscopy; online system; photooxidation; prenylation; protein synthesis inhibition; structure analysis; ultraviolet spectroscopy; 6,8-diprenylorobol; A2E photooxidation; Cudrania tricuspidata; Online HPLC-ABTS + system; Pomiferin; Prenylated isoflavonoids
ISSN
1226-3907
URI
https://pubs.kist.re.kr/handle/201004/130057
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KIST Article > 2011
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