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dc.contributor.authorChoi, Man Ho-
dc.contributor.authorMoon, Ju-Yeon-
dc.contributor.authorCho, Sung-Hee-
dc.contributor.authorChung, Bong Chul-
dc.contributor.authorLee, Eun Jig-
dc.date.accessioned2024-01-20T16:32:17Z-
dc.date.available2024-01-20T16:32:17Z-
dc.date.created2021-09-04-
dc.date.issued2011-08-08-
dc.identifier.issn1471-2407-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/130079-
dc.description.abstractBackground: To evaluate the metabolic changes in urinary steroids in pre- and post-menopausal women and men with papillary thyroid carcinoma (PTC). Methods: Quantitative steroid profiling combined with gas chromatography-mass spectrometry was used to measure the urinary concentrations of 84 steroids in both pre- (n = 21, age: 36.95 +/- 7.19 yr) and post-menopausal female (n = 19, age: 52.79 +/- 7.66 yr), and male (n = 16, age: 41.88 +/- 8.48 yr) patients with PTC. After comparing the quantitative data of the patients with their corresponding controls (pre-menopause women: n = 24, age: 33.21 +/- 10.48 yr, post-menopause women: n = 16, age: 49.67 +/- 8.94 yr, male: n = 20, age: 42.75 +/- 4.22 yr), the levels of steroids in the patients were normalized to the mean concentration of the controls to exclude gender and menopausal variations. Results: Many urinary steroids were up-regulated in all PTC patients compared to the controls. Among them, the levels of three active androgens, androstenedione, androstenediol and 16 alpha-hydroxy DHEA, were significantly higher in the pre-menopausal women and men with PTC. The corticoid levels were increased slightly in the PTC men, while progestins were not altered in the post-menopausal PTC women. Estrogens were up-regulated in all PTC patients but 2-hydroxyestrone and 2-hydroxy-17 beta-estradiol were remarkably changed in both pre-menopausal women and men with PTC. For both menopausal and gender differences, the 2-hydroxylation, 4-hydroxylation, 2-methoxylation, and 4-methoxylation of estrogens and 16 alpha-hydroxylation of DHEA were differentiated between pre- and post-menopausal PTC women (P < 0.001). In particular, the metabolic ratio of 2-hydroxyestrone to 2-hydroxy-17 beta-estradiol, which could reveal the enzyme activity of 17 beta-hydroxysteroid dehydrogenase, showed gender differences in PTC patients (P < 1 x 10(-7)). Conclusions: These results are expected be helpful for better understanding the pathogenic differences in PTC according to gender and menopausal conditions.-
dc.languageEnglish-
dc.publisherBIOMED CENTRAL LTD-
dc.subjectESTROGEN-RECEPTOR-
dc.subjectMOLECULAR MECHANISMS-
dc.subjectANDROGEN RECEPTORS-
dc.subjectPOOLED ANALYSIS-
dc.subjectBREAST-CANCER-
dc.subjectDNA-DAMAGE-
dc.subjectCELLS-
dc.subjectGROWTH-
dc.subjectTUMORS-
dc.subjectRISK-
dc.titleMetabolic alteration of urinary steroids in pre- and post-menopausal women, and men with papillary thyroid carcinoma-
dc.typeArticle-
dc.identifier.doi10.1186/1471-2407-11-342-
dc.description.journalClass1-
dc.identifier.bibliographicCitationBMC CANCER, v.11-
dc.citation.titleBMC CANCER-
dc.citation.volume11-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.identifier.wosid000294407400001-
dc.identifier.scopusid2-s2.0-79961108678-
dc.relation.journalWebOfScienceCategoryOncology-
dc.relation.journalResearchAreaOncology-
dc.type.docTypeArticle-
dc.subject.keywordPlusESTROGEN-RECEPTOR-
dc.subject.keywordPlusMOLECULAR MECHANISMS-
dc.subject.keywordPlusANDROGEN RECEPTORS-
dc.subject.keywordPlusPOOLED ANALYSIS-
dc.subject.keywordPlusBREAST-CANCER-
dc.subject.keywordPlusDNA-DAMAGE-
dc.subject.keywordPlusCELLS-
dc.subject.keywordPlusGROWTH-
dc.subject.keywordPlusTUMORS-
dc.subject.keywordPlusRISK-
dc.subject.keywordAuthorSteroids-
dc.subject.keywordAuthorThyroid cancer-
dc.subject.keywordAuthorMenopause-
dc.subject.keywordAuthorGender difference-
dc.subject.keywordAuthorGC-MS-
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