Synthesis of PEO-Based Glucose-Sensitive Block Copolymers and Their Application for Preparation of Superparamagnetic Iron Oxide Nanoparticles

Abstract

Amphiphilic block copolymers were synthesized by reversible addition fragmentation chain transfer (RAFT) radical block polymerization of N-vinylimidazole and 3-(methacrylamido) phenylboronic acid using poly (ethylene oxide) (PEO)-based xanthate type of RAFT agent and 2,2'-azobisisobutyronitrile (AIBN) in dimethylformaide (DMF) at 90 similar to 110 degrees C for 24 h. Poly(ethylene oxide-b-3-(methacrylamido) phenylboronic acid) and poly(ethylene oxide-b-N-vinylimidazole-b-3-(methacrylamido) phenylboronic acid) were prepared successfully through the sequential monomer addition method. Both block copolymers were found to exhibit glucose-responsive behavior via the feasibility test for complex formation with Alizarin Red S (ARS). The ratio of molecular weight of the poly(N-vinyimidazole) to the poly(3-(methacrylamido) phenylboronic acid) appeared to play an important role in the pH-& glucose-responsive behavior. The resulting block copolymers were used successfully as polymeric stabilizers to prepare water-soluble Fe(3)O(4) nanoparticles. All the materials were characterized by the combination of (1)H nuclear magnetic resonance (NMR), size exclusion chromatography (SEC), transmission electron microscopy (TEM), thermogravimetric analysis (TGA), and x-ray diffraction (XRD) analyses.