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dc.contributor.authorKim, Jihoon-
dc.contributor.authorLee, Yanggy-
dc.contributor.authorSingha, Kaushik-
dc.contributor.authorKim, Hyun Woo-
dc.contributor.authorShin, Jae Ho-
dc.contributor.authorJo, Seongbong-
dc.contributor.authorHan, Dong-Keun-
dc.contributor.authorKim, Won Jong-
dc.date.accessioned2024-01-20T17:01:59Z-
dc.date.available2024-01-20T17:01:59Z-
dc.date.created2021-09-04-
dc.date.issued2011-06-
dc.identifier.issn1043-1802-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/130321-
dc.description.abstractIn recent years, numerous research activities have been devoted to the controlled release of nitric oxide (NO) due to its potential as a restenosis inhibitor which inhibits the proliferation of vascular smooth muscle cells, the apoptosis of vascular endothelial cells, and aggregation of platelets. This work has demonstrated the development of a novel NO-conjugated gel system comprising of thermosensitive Pluronic F127, branched polyethylenimine (BPEI), and diazeniumdiolates (NONOates). Synthesis of conjugated Pluronic-BPEI-NONOates involved coupling of activated F127 to BPEI followed by the installation of NONOates at the secondary amine sites of branched PEI backbone under high pressure. NO-conjugated gel system, F127-BPEI-NONOates, reduced the initial burst of NO release and prolonged NO release. Furthermore, F127-BPEI-NONOates polymer coated on cell culture dish displayed much higher increase of endothelial cell proliferation and reduction of smooth muscle cell proliferation than that exhibited by non-NO releasing control. Such an NO-releasing device can operate locally and has a great potential in several biomedical applications due to high biocompatibility imparted by the conjugated F127.-
dc.languageEnglish-
dc.publisherAMER CHEMICAL SOC-
dc.subjectSILICA NANOPARTICLES-
dc.subjectPOLY(VINYL ALCOHOL)-
dc.subjectPLATELET-ADHESION-
dc.subjectBLOCK-COPOLYMERS-
dc.subjectRESTENOSIS-
dc.subjectDONOR-
dc.subjectINDUCTION-
dc.subjectPOLYMERS-
dc.subjectSCAFFOLD-
dc.subjectDELIVERY-
dc.titleNONOates-Polyethylenimine Hydrogel for Controlled Nitric Oxide Release and Cell Proliferation Modulation-
dc.typeArticle-
dc.identifier.doi10.1021/bc100405c-
dc.description.journalClass1-
dc.identifier.bibliographicCitationBIOCONJUGATE CHEMISTRY, v.22, no.6, pp.1031 - 1038-
dc.citation.titleBIOCONJUGATE CHEMISTRY-
dc.citation.volume22-
dc.citation.number6-
dc.citation.startPage1031-
dc.citation.endPage1038-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.identifier.wosid000291568200007-
dc.identifier.scopusid2-s2.0-79959256071-
dc.relation.journalWebOfScienceCategoryBiochemical Research Methods-
dc.relation.journalWebOfScienceCategoryBiochemistry & Molecular Biology-
dc.relation.journalWebOfScienceCategoryChemistry, Multidisciplinary-
dc.relation.journalWebOfScienceCategoryChemistry, Organic-
dc.relation.journalResearchAreaBiochemistry & Molecular Biology-
dc.relation.journalResearchAreaChemistry-
dc.type.docTypeArticle-
dc.subject.keywordPlusSILICA NANOPARTICLES-
dc.subject.keywordPlusPOLY(VINYL ALCOHOL)-
dc.subject.keywordPlusPLATELET-ADHESION-
dc.subject.keywordPlusBLOCK-COPOLYMERS-
dc.subject.keywordPlusRESTENOSIS-
dc.subject.keywordPlusDONOR-
dc.subject.keywordPlusINDUCTION-
dc.subject.keywordPlusPOLYMERS-
dc.subject.keywordPlusSCAFFOLD-
dc.subject.keywordPlusDELIVERY-
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KIST Article > 2011
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