Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Kim, Jihoon | - |
dc.contributor.author | Lee, Yanggy | - |
dc.contributor.author | Singha, Kaushik | - |
dc.contributor.author | Kim, Hyun Woo | - |
dc.contributor.author | Shin, Jae Ho | - |
dc.contributor.author | Jo, Seongbong | - |
dc.contributor.author | Han, Dong-Keun | - |
dc.contributor.author | Kim, Won Jong | - |
dc.date.accessioned | 2024-01-20T17:01:59Z | - |
dc.date.available | 2024-01-20T17:01:59Z | - |
dc.date.created | 2021-09-04 | - |
dc.date.issued | 2011-06 | - |
dc.identifier.issn | 1043-1802 | - |
dc.identifier.uri | https://pubs.kist.re.kr/handle/201004/130321 | - |
dc.description.abstract | In recent years, numerous research activities have been devoted to the controlled release of nitric oxide (NO) due to its potential as a restenosis inhibitor which inhibits the proliferation of vascular smooth muscle cells, the apoptosis of vascular endothelial cells, and aggregation of platelets. This work has demonstrated the development of a novel NO-conjugated gel system comprising of thermosensitive Pluronic F127, branched polyethylenimine (BPEI), and diazeniumdiolates (NONOates). Synthesis of conjugated Pluronic-BPEI-NONOates involved coupling of activated F127 to BPEI followed by the installation of NONOates at the secondary amine sites of branched PEI backbone under high pressure. NO-conjugated gel system, F127-BPEI-NONOates, reduced the initial burst of NO release and prolonged NO release. Furthermore, F127-BPEI-NONOates polymer coated on cell culture dish displayed much higher increase of endothelial cell proliferation and reduction of smooth muscle cell proliferation than that exhibited by non-NO releasing control. Such an NO-releasing device can operate locally and has a great potential in several biomedical applications due to high biocompatibility imparted by the conjugated F127. | - |
dc.language | English | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.subject | SILICA NANOPARTICLES | - |
dc.subject | POLY(VINYL ALCOHOL) | - |
dc.subject | PLATELET-ADHESION | - |
dc.subject | BLOCK-COPOLYMERS | - |
dc.subject | RESTENOSIS | - |
dc.subject | DONOR | - |
dc.subject | INDUCTION | - |
dc.subject | POLYMERS | - |
dc.subject | SCAFFOLD | - |
dc.subject | DELIVERY | - |
dc.title | NONOates-Polyethylenimine Hydrogel for Controlled Nitric Oxide Release and Cell Proliferation Modulation | - |
dc.type | Article | - |
dc.identifier.doi | 10.1021/bc100405c | - |
dc.description.journalClass | 1 | - |
dc.identifier.bibliographicCitation | BIOCONJUGATE CHEMISTRY, v.22, no.6, pp.1031 - 1038 | - |
dc.citation.title | BIOCONJUGATE CHEMISTRY | - |
dc.citation.volume | 22 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 1031 | - |
dc.citation.endPage | 1038 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.identifier.wosid | 000291568200007 | - |
dc.identifier.scopusid | 2-s2.0-79959256071 | - |
dc.relation.journalWebOfScienceCategory | Biochemical Research Methods | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Organic | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | SILICA NANOPARTICLES | - |
dc.subject.keywordPlus | POLY(VINYL ALCOHOL) | - |
dc.subject.keywordPlus | PLATELET-ADHESION | - |
dc.subject.keywordPlus | BLOCK-COPOLYMERS | - |
dc.subject.keywordPlus | RESTENOSIS | - |
dc.subject.keywordPlus | DONOR | - |
dc.subject.keywordPlus | INDUCTION | - |
dc.subject.keywordPlus | POLYMERS | - |
dc.subject.keywordPlus | SCAFFOLD | - |
dc.subject.keywordPlus | DELIVERY | - |
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