Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Kim, Sang Hoon | - |
dc.contributor.author | Lee, Young Hoon | - |
dc.contributor.author | Jung, Seo Yun | - |
dc.contributor.author | Kim, Hyoung Ja | - |
dc.contributor.author | Jin, Changbae | - |
dc.contributor.author | Lee, Yong Sup | - |
dc.date.accessioned | 2024-01-20T17:04:01Z | - |
dc.date.available | 2024-01-20T17:04:01Z | - |
dc.date.created | 2021-09-02 | - |
dc.date.issued | 2011-05 | - |
dc.identifier.issn | 0223-5234 | - |
dc.identifier.uri | https://pubs.kist.re.kr/handle/201004/130421 | - |
dc.description.abstract | The overactivation of mu-calpain can cause serious cell damage in several diseases. Furthermore, cell death in a number of neurodegenerative disorders is linked to the overproduction of reactive oxygen species. Therefore, antioxidants and mu-calpain inhibitors could have the therapeutic potentials to treat cell death related diseases. New chromone carboxamide derivatives 3 were synthesized to provide alternative mu-calpain inhibitors to compound 2, a conformationally constrained structural variant of MDL 28,170. Compounds 3h and 3l exhibited the most potent p-calpain inhibitory activities (IC50 = 0.09-0.10 mu M), and were comparable to 2 in this respect (IC50 = 0.07 mu M). Compound 31 showed both potent p-calpain inhibitory activity (IC50 = 0.28 mu M) and antioxidant activities in DPPH scavenging and lipid peroxidation inhibition assays. (C) 2011 Elsevier Masson SAS. All rights reserved. | - |
dc.language | English | - |
dc.publisher | ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER | - |
dc.subject | MOUSE MODEL | - |
dc.subject | DISEASE | - |
dc.subject | ACTIVATION | - |
dc.subject | APOPTOSIS | - |
dc.subject | STRESS | - |
dc.subject | DESIGN | - |
dc.subject | SYSTEM | - |
dc.subject | RATS | - |
dc.title | Synthesis of chromone carboxamide derivatives with antioxidative and calpain inhibitory properties | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.ejmech.2011.02.025 | - |
dc.description.journalClass | 1 | - |
dc.identifier.bibliographicCitation | EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, v.46, no.5, pp.1721 - 1728 | - |
dc.citation.title | EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | - |
dc.citation.volume | 46 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 1721 | - |
dc.citation.endPage | 1728 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.identifier.wosid | 000289655100030 | - |
dc.identifier.scopusid | 2-s2.0-79953171480 | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | MOUSE MODEL | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | STRESS | - |
dc.subject.keywordPlus | DESIGN | - |
dc.subject.keywordPlus | SYSTEM | - |
dc.subject.keywordPlus | RATS | - |
dc.subject.keywordAuthor | Calpain inhibitor | - |
dc.subject.keywordAuthor | Cell death | - |
dc.subject.keywordAuthor | Neurodegenerative disease | - |
dc.subject.keywordAuthor | Chromone carboxamide | - |
dc.subject.keywordAuthor | Antioxidant | - |
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