DSpace at KISTKIST Article2011

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dc.contributor.authorEl-Gamal, Mohammed I.-
dc.contributor.authorSim, Tae Bo-
dc.contributor.authorHong, Jun Hee-
dc.contributor.authorCho, Jung-Hyuck-
dc.contributor.authorYoo, Kyung Ho-
dc.contributor.authorOh, Chang-Hyun-
dc.date.accessioned2024-01-20T17:31:41Z-
dc.date.available2024-01-20T17:31:41Z-
dc.date.created2022-01-10-
dc.date.issued2011-03-
dc.identifier.issn0365-6233-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/130555-
dc.description.abstractSynthesis of a new series of 1H-pyrazole-1-carboxamide derivatives is described. Their antiproliferative activity against A375 human melanoma cell line was tested and the effect of substituents on the diarylpyrazole scaffold was investigated. The pharmacological results indicated that most of the newly synthesized compounds showed moderate activity against A375, compared with sorafenib. Among all of these derivatives, compound IIe which has N-methylpiperazinyl and phenolic moieties showed the most potent antiproliferative activity against A375 human melanoma cell line.-
dc.languageEnglish-
dc.publisherWILEY-V C H VERLAG GMBH-
dc.subjectREFRACTORY SOLID TUMORS-
dc.subjectFACTOR RECEPTOR INHIBITOR-
dc.subjectRAF KINASE-
dc.subjectMETASTATIC MELANOMA-
dc.subjectPHASE-I-
dc.subjectSORAFENIB-
dc.subjectBAY-43-9006-
dc.subjectTHERAPY-
dc.subjectPHARMACOKINETICS-
dc.subjectINTERLEUKIN-2-
dc.titleSynthesis of 1H-Pyrazole-1-carboxamide Derivatives and Their Antiproliferative Activity against Melanoma Cell Line-
dc.typeArticle-
dc.identifier.doi10.1002/ardp.201000057-
dc.description.journalClass1-
dc.identifier.bibliographicCitationARCHIV DER PHARMAZIE, v.344, no.3, pp.197 - 204-
dc.citation.titleARCHIV DER PHARMAZIE-
dc.citation.volume344-
dc.citation.number3-
dc.citation.startPage197-
dc.citation.endPage204-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.identifier.wosid000288092900008-
dc.identifier.scopusid2-s2.0-79952524606-
dc.relation.journalWebOfScienceCategoryChemistry, Medicinal-
dc.relation.journalWebOfScienceCategoryChemistry, Multidisciplinary-
dc.relation.journalWebOfScienceCategoryPharmacology & Pharmacy-
dc.relation.journalResearchAreaPharmacology & Pharmacy-
dc.relation.journalResearchAreaChemistry-
dc.type.docTypeArticle-
dc.subject.keywordPlusREFRACTORY SOLID TUMORS-
dc.subject.keywordPlusFACTOR RECEPTOR INHIBITOR-
dc.subject.keywordPlusRAF KINASE-
dc.subject.keywordPlusMETASTATIC MELANOMA-
dc.subject.keywordPlusPHASE-I-
dc.subject.keywordPlusSORAFENIB-
dc.subject.keywordPlusBAY-43-9006-
dc.subject.keywordPlusTHERAPY-
dc.subject.keywordPlusPHARMACOKINETICS-
dc.subject.keywordPlusINTERLEUKIN-2-
dc.subject.keywordAuthorA375-
dc.subject.keywordAuthorAntiproliferative activity-
dc.subject.keywordAuthor3,4-Diarylpyrazole-
dc.subject.keywordAuthorMelanoma-
dc.subject.keywordAuthor1H-Pyrazole-1-carboxamide-
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