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dc.contributor.authorJo, Nam Hyun-
dc.contributor.authorKim, Jung Young-
dc.contributor.authorEl-Gamal, Mohammed I.-
dc.contributor.authorChoi, Won-Kyoung-
dc.contributor.authorPark, Jin-Hun-
dc.contributor.authorKim, Eun Jung-
dc.contributor.authorCho, Jung-Hyuck-
dc.contributor.authorHa, Hyun-Joon-
dc.contributor.authorChoi, Tae Hyun-
dc.contributor.authorOh, Chang-Hyun-
dc.date.accessioned2024-01-20T17:33:48Z-
dc.date.available2024-01-20T17:33:48Z-
dc.date.created2022-01-10-
dc.date.issued2011-02-
dc.identifier.issn0362-4803-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/130659-
dc.description.abstractSynthesis, radiolabelling, and in vitro evaluation of a new I-125-labelled iodouracil hexitol nucleoside analogue are reported. The target compound was successfully synthesized by an iodination-destannylation method and then purified by reverse phase HPLC. The radiochemical purity of the product was >99% with decay-corrected yields of 48 +/- 3%. In vitro cellular uptake testing was carried out using MCA and MCA-tk cell lines for comparison of compound 1 with [F-18] FHBG. The newly synthesized compound 1 showed higher accumulation in herpex simplex virus type 1 thymidine kinase (HSV1-tk) gene expression cell line (MCA-tk cell line) than in the wild type MCA cell line compared with [18 F] FHBG. The MCA-tk to MCA cellular uptake ratio for compound 1 was higher than that of [F-18] FHBG from 2 h after incubation. The radioiodine-labelled compound 1 (I-125, t(1/2) = 59.37 days) has a longer physical half-life than F-18-(t(1/2) = 110 min) labelled FHBG. Radioiodine-labelled compound 1 could be used for monitoring gene expression for a long time. The selectivity for MCA-tk cell line makes compound 1 a promising imaging agent for HSV1-tk expression.-
dc.languageEnglish-
dc.publisherWILEY-BLACKWELL-
dc.subjectTHYMIDINE KINASE GENE-
dc.subjectPET IMAGING AGENT-
dc.subjectEXPRESSION-
dc.subjectTHERAPY-
dc.subjectFIAU-
dc.subjectNUCLEOSIDES-
dc.subjectANALOGS-
dc.subjectPROBES-
dc.subjectSUGAR-
dc.subjectFHPG-
dc.titleRadiosynthesis and in vitro evaluation of 1-(tetrahydro-5-hydroxy-6-(hydroxymethyl)-2H-pyran-3-yl)-5-[I-125]iodour acil: A new potential agent for HSV1-tk reporter gene monitoring-
dc.typeArticle-
dc.identifier.doi10.1002/jlcr.1819-
dc.description.journalClass1-
dc.identifier.bibliographicCitationJOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, v.54, no.2, pp.93 - 97-
dc.citation.titleJOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS-
dc.citation.volume54-
dc.citation.number2-
dc.citation.startPage93-
dc.citation.endPage97-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.identifier.wosid000287612500007-
dc.identifier.scopusid2-s2.0-79951733519-
dc.relation.journalWebOfScienceCategoryBiochemical Research Methods-
dc.relation.journalWebOfScienceCategoryChemistry, Medicinal-
dc.relation.journalWebOfScienceCategoryChemistry, Analytical-
dc.relation.journalResearchAreaBiochemistry & Molecular Biology-
dc.relation.journalResearchAreaPharmacology & Pharmacy-
dc.relation.journalResearchAreaChemistry-
dc.type.docTypeArticle-
dc.subject.keywordPlusTHYMIDINE KINASE GENE-
dc.subject.keywordPlusPET IMAGING AGENT-
dc.subject.keywordPlusEXPRESSION-
dc.subject.keywordPlusTHERAPY-
dc.subject.keywordPlusFIAU-
dc.subject.keywordPlusNUCLEOSIDES-
dc.subject.keywordPlusANALOGS-
dc.subject.keywordPlusPROBES-
dc.subject.keywordPlusSUGAR-
dc.subject.keywordPlusFHPG-
dc.subject.keywordAuthorHSV1-tk-
dc.subject.keywordAuthornucleoside-
dc.subject.keywordAuthorhexitol-
dc.subject.keywordAuthoriodouracil-
dc.subject.keywordAuthorMCA-tk-
dc.subject.keywordAuthorMCA-
dc.subject.keywordAuthoriodine-125-
dc.subject.keywordAuthorimaging agents-
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