DSpace at KISTKIST Article2011

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dc.contributor.authorChoi, Yeon-hee-
dc.contributor.authorBaek, Du Jong-
dc.contributor.authorSeo, Seon Hee-
dc.contributor.authorLee, Jae Kyun-
dc.contributor.authorPae, Ae Nim-
dc.contributor.authorCho, Yong Seo-
dc.contributor.authorMin, Sun-Joon-
dc.date.accessioned2024-01-20T18:01:46Z-
dc.date.available2024-01-20T18:01:46Z-
dc.date.created2021-09-02-
dc.date.issued2011-01-
dc.identifier.issn0960-894X-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/130797-
dc.description.abstractWe have developed a facile synthesis of 3,3-diphenylpropanamides using Meldrum's acid derivatives as amide coupling components. The in vitro biological evaluation of the title compounds led to the identification of compound 1h, which has good inhibitory activity against T-type calcium channel (IC50 = 0.83 mu M). (C) 2010 Elsevier Ltd. All rights reserved.-
dc.languageEnglish-
dc.publisherPergamon Press Ltd.-
dc.subjectMELDRUMS ACIDS-
dc.subjectDERIVATIVES-
dc.subjectEFFICIENT-
dc.subjectANALOGS-
dc.titleFacile synthesis and biological evaluation of 3,3-diphenylpropanoyl piperazines as T-type calcium channel blockers-
dc.typeArticle-
dc.identifier.doi10.1016/j.bmcl.2010.11.033-
dc.description.journalClass1-
dc.identifier.bibliographicCitationBioorganic & Medicinal Chemistry Letters, v.21, no.1, pp.215 - 219-
dc.citation.titleBioorganic & Medicinal Chemistry Letters-
dc.citation.volume21-
dc.citation.number1-
dc.citation.startPage215-
dc.citation.endPage219-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.identifier.wosid000285544400041-
dc.identifier.scopusid2-s2.0-78650511276-
dc.relation.journalWebOfScienceCategoryChemistry, Medicinal-
dc.relation.journalWebOfScienceCategoryChemistry, Organic-
dc.relation.journalResearchAreaPharmacology & Pharmacy-
dc.relation.journalResearchAreaChemistry-
dc.type.docTypeArticle-
dc.subject.keywordPlusMELDRUMS ACIDS-
dc.subject.keywordPlusDERIVATIVES-
dc.subject.keywordPlusEFFICIENT-
dc.subject.keywordPlusANALOGS-
dc.subject.keywordAuthorT-Type calcium channel blockers-
dc.subject.keywordAuthorMeldrum&apos-
dc.subject.keywordAuthors acid-
dc.subject.keywordAuthor3,3-Diphenylpropanoyl piperazine-
dc.subject.keywordAuthorHTS assays-
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