DSpace at KISTKIST Article2009

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dc.contributor.authorHong, Joon Hee-
dc.contributor.authorOh, Chang Hyun-
dc.date.accessioned2024-01-20T20:33:30Z-
dc.date.available2024-01-20T20:33:30Z-
dc.date.created2021-09-05-
dc.date.issued2009-10-
dc.identifier.issn0365-6233-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/132100-
dc.description.abstractThis paper reports the synthesis of novel 4'-hydrophobic pocket deoxythreosyl C-nucleosides. The key threose-like intermediates 9 and 14 were constructed from acyclic ketone derivatives, respectively. The antiviral activities of the synthesized compounds against the HIV-1, HSV-1, HSV-2, and HCMV viruses were evaluated. The 9-deaza-adenine derivatives 10 and 20 showed good anti-HIV activity without exhibiting significant cytotoxicity.-
dc.languageEnglish-
dc.publisherWILEY-V C H VERLAG GMBH-
dc.subjectISOMERIC DIDEOXYNUCLEOSIDES-
dc.subject9-DEAZAADENOSINE-
dc.subjectNUCLEOSIDES-
dc.titleSynthesis and In-vitro Activity of 4 '-Modified Analogues of ddA as Potent Anti-HIV Agents-
dc.typeArticle-
dc.identifier.doi10.1002/ardp.200900063-
dc.description.journalClass1-
dc.identifier.bibliographicCitationARCHIV DER PHARMAZIE, v.342, no.10, pp.600 - 604-
dc.citation.titleARCHIV DER PHARMAZIE-
dc.citation.volume342-
dc.citation.number10-
dc.citation.startPage600-
dc.citation.endPage604-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.identifier.wosid000271132300006-
dc.identifier.scopusid2-s2.0-70349651010-
dc.relation.journalWebOfScienceCategoryChemistry, Medicinal-
dc.relation.journalWebOfScienceCategoryChemistry, Multidisciplinary-
dc.relation.journalWebOfScienceCategoryPharmacology & Pharmacy-
dc.relation.journalResearchAreaPharmacology & Pharmacy-
dc.relation.journalResearchAreaChemistry-
dc.type.docTypeArticle-
dc.subject.keywordPlusISOMERIC DIDEOXYNUCLEOSIDES-
dc.subject.keywordPlus9-DEAZAADENOSINE-
dc.subject.keywordPlusNUCLEOSIDES-
dc.subject.keywordAuthorAntiviral agents-
dc.subject.keywordAuthorDeoxythreosyl C-Nucleoside-
dc.subject.keywordAuthorOzonolysis-
dc.subject.keywordAuthorPhosphorylation-
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