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dc.contributor.authorOh, Chang Hyun-
dc.contributor.authorLiu, Lian Jin-
dc.contributor.authorHong, Joon Hee-
dc.date.accessioned2024-01-20T22:34:29Z-
dc.date.available2024-01-20T22:34:29Z-
dc.date.created2021-09-02-
dc.date.issued2008-10-
dc.identifier.issn1525-7770-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/133131-
dc.description.abstractThe first synthesis of a 4'-methylated carbocyclic C-nucleoside 16 was achieved via the mesylate intermediate 10, which was prepared using ring-closing metathesis and S(N)2 alkylation from acetol 5. When antiviral evaluation of synthesized compound 16 was performed against various viruses such as HIV, HSV-1, HSV-2, and HCMV, it showed moderate anti-HIV activity in MT-4 cell line (EC50 = 14.7 mu mol).-
dc.languageEnglish-
dc.publisherTAYLOR & FRANCIS INC-
dc.subjectANTIVIRAL ACTIVITY-
dc.subjectENANTIOSELECTIVE SYNTHESIS-
dc.subjectPOTENT INHIBITORS-
dc.subjectC-NUCLEOSIDES-
dc.subjectANALOGS-
dc.titleFirst synthesis and anti-HIV evaluation of 4 '-methyl-cyclopentanyl 9-deazaadenosine-
dc.typeArticle-
dc.identifier.doi10.1080/15257770802341392-
dc.description.journalClass1-
dc.identifier.bibliographicCitationNUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, v.27, no.10-11, pp.1144 - 1152-
dc.citation.titleNUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS-
dc.citation.volume27-
dc.citation.number10-11-
dc.citation.startPage1144-
dc.citation.endPage1152-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.identifier.wosid000259146100005-
dc.identifier.scopusid2-s2.0-51649095182-
dc.relation.journalWebOfScienceCategoryBiochemistry & Molecular Biology-
dc.relation.journalResearchAreaBiochemistry & Molecular Biology-
dc.type.docTypeArticle-
dc.subject.keywordPlusANTIVIRAL ACTIVITY-
dc.subject.keywordPlusENANTIOSELECTIVE SYNTHESIS-
dc.subject.keywordPlusPOTENT INHIBITORS-
dc.subject.keywordPlusC-NUCLEOSIDES-
dc.subject.keywordPlusANALOGS-
dc.subject.keywordAuthorcarbocyclic C-nucleoside-
dc.subject.keywordAuthorantiviral agents-
dc.subject.keywordAuthorS(N)2 alkylation-
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