Full metadata record

DC Field Value Language
dc.contributor.author김승용-
dc.contributor.author정연복-
dc.contributor.author표희수-
dc.contributor.author권오승-
dc.date.accessioned2024-01-20T23:01:08Z-
dc.date.available2024-01-20T23:01:08Z-
dc.date.created2021-09-06-
dc.date.issued2008-08-
dc.identifier.issn2093-5552-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/133266-
dc.description.abstractA sensitive and simple method of determining the plasma levofloxacin (LFX, CAS 100986-85-4) concentrations in human volunteers by liquid-liquid extraction were developed and validated by using a high-performance liquid chromatography/diode array detector. The method was also applied to armacokinetic study of LFX. LFX was orally administered to 8 healthy male Korean volunteers at single lowest dose of 200 mg, compared to the published reports in which more than 500 mg of LFX was orally administered. LFX in human plasma was determined. The detection limit of LFX was 0.05 μg/mL. Cmax value was 2.48 ± 0.67 μg/mL. AUC0→24 hr and AUC0→∞ were 14.52 ± 3.35 μg/mL and 16.00 ± 3.66 μg · hr/mL, respectively. The terminal half-life was 6.87±0.46 hr. Our pharmacokinetic parameters were very consistent with that previously reported, showing good correlation between LFX doses and AUC (r2=0.995). This method can be useful for the pharmacokinetics and bioequivalence study with relatively low dose for reducing the main side effects of LFX.-
dc.languageEnglish-
dc.publisher한국약제학회-
dc.titlePharmacokinetic Analysis of Levofloxacin in Healthy Korean Volunteers-
dc.typeArticle-
dc.description.journalClass2-
dc.identifier.bibliographicCitationJournal of Pharmaceutical Investigation, v.38, no.4, pp.235 - 240-
dc.citation.titleJournal of Pharmaceutical Investigation-
dc.citation.volume38-
dc.citation.number4-
dc.citation.startPage235-
dc.citation.endPage240-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClasskci-
dc.identifier.kciidART001270102-
dc.subject.keywordAuthorLevofloxacin-
dc.subject.keywordAuthorAntibiotics-
dc.subject.keywordAuthorPharmacokinetics-
dc.subject.keywordAuthorHuman volunteers-
dc.subject.keywordAuthorHigh-performance liquid chromatography-
Appears in Collections:
KIST Article > 2008
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE