Full metadata record

DC Field Value Language
dc.contributor.authorYoon, Juhee-
dc.contributor.authorYoo, Eun A.-
dc.contributor.authorKim, Ji-Yeon-
dc.contributor.authorPae, Ae Nim-
dc.contributor.authorRhim, Hyewhon-
dc.contributor.authorPark, Woo-Kyu-
dc.contributor.authorKong, Jae Yang-
dc.contributor.authorChoo, Hea-Young Park-
dc.date.accessioned2024-01-20T23:05:43Z-
dc.date.available2024-01-20T23:05:43Z-
dc.date.created2021-09-03-
dc.date.issued2008-05-15-
dc.identifier.issn0968-0896-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/133490-
dc.description.abstractTwenty-four compounds of 4-methoxy-N-[3-(4-substituted phenyl-piperazine-1-yl) propyl] benzene sulfonamides and N-[3-(4- substituted phenyl-piperazine-1-yl) propyl] naphthyl sulfonamides were prepared and evaluated as 5-HT7 receptor antagonists. Most of the compounds showed the IC50 values of 12-580 nM. Four methyl branched analogues were also obtained, but the activity for methyl branched analogues was almost same as its straight chain congeners. Among the synthesized compounds, 3c showed a good activity on 5-HT7 receptors and a good selectivity on 5-HT1a, 5-HT2a, 5-HT2c, and 5-HT6 receptors. (C) 2008 Elsevier Ltd. All rights reserved.-
dc.languageEnglish-
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD-
dc.subjectPOTENT-
dc.titlePreparation of piperazine derivatives as 5-HT7 receptor antagonists-
dc.typeArticle-
dc.identifier.doi10.1016/j.bmc.2008.04.023-
dc.description.journalClass1-
dc.identifier.bibliographicCitationBIOORGANIC & MEDICINAL CHEMISTRY, v.16, no.10, pp.5405 - 5412-
dc.citation.titleBIOORGANIC & MEDICINAL CHEMISTRY-
dc.citation.volume16-
dc.citation.number10-
dc.citation.startPage5405-
dc.citation.endPage5412-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.identifier.wosid000256052400005-
dc.identifier.scopusid2-s2.0-43749091957-
dc.relation.journalWebOfScienceCategoryBiochemistry & Molecular Biology-
dc.relation.journalWebOfScienceCategoryChemistry, Medicinal-
dc.relation.journalWebOfScienceCategoryChemistry, Organic-
dc.relation.journalResearchAreaBiochemistry & Molecular Biology-
dc.relation.journalResearchAreaPharmacology & Pharmacy-
dc.relation.journalResearchAreaChemistry-
dc.type.docTypeArticle-
dc.subject.keywordPlusPOTENT-
dc.subject.keywordAuthor5-HT7 receptor antagonists-
dc.subject.keywordAuthorpiperazine-
dc.subject.keywordAuthorsulfonamide-
dc.subject.keywordAuthor5-HT2c receptor antagonists.-
Appears in Collections:
KIST Article > 2008
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE