DSpace at KIST: Selective vasodilatation effect of sargahydroquinoic acid, an active constituent of Sargassum micracanthum, on the basilar arteries of rabbits

Selective vasodilatation effect of sargahydroquinoic acid, an active constituent of Sargassum micracanthum, on the basilar arteries of rabbits

Authors: Park, Byong-Gon; Shin, Woon-Seob; Um, Yumi; Cho, Sungsik; Park, Gab-Man; Yeon, Dong-Soo; Kwon, Seong-Chun; Ham, Jungyeob; Choi, Byoung Wook; Lee, Seokjoon

Citation: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.18, no.8, pp.2624 - 2627

Abstract: Sargahydroquinoic acid (2), a major active constituent of Sargassum micracanthum collected from the coast of the East Sea in Korea, showed a selective vasodilatation effect on the basilar arteries of rabbits. Therefore, treatment with sargahydroquinoic acid may selectively accelerate cerebral blood flow through dilatation of the basilar artery without lowering systemic blood pressure. (c) 2008 Elsevier Ltd. All rights reserved.

Keywords: BROWN-ALGA; ENDOTHELIN-1-INDUCED CONTRACTION; SUBARACHNOID HEMORRHAGE; ANTIVIRAL ACTIVITIES; PLASTOQUINONES; ANTIOXIDANT; NICARDIPINE; DERIVATIVES; SAGAMIANUM; VASOSPASM; BROWN-ALGA; ENDOTHELIN-1-INDUCED CONTRACTION; SUBARACHNOID HEMORRHAGE; ANTIVIRAL ACTIVITIES; PLASTOQUINONES; ANTIOXIDANT; NICARDIPINE; DERIVATIVES; SAGAMIANUM; VASOSPASM; natural product; sargahydroquinoic acid; vasodilatation; basilar artery; cerebrovascular diseases

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