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dc.contributor.authorHajduch, Jan-
dc.contributor.authorNam, Ghilsoo-
dc.contributor.authorKim, Eun Ju-
dc.contributor.authorFroehlich, Roland-
dc.contributor.authorHanover, John A.-
dc.contributor.authorKirk, Kenneth L.-
dc.date.accessioned2024-01-20T23:35:29Z-
dc.date.available2024-01-20T23:35:29Z-
dc.date.created2021-08-31-
dc.date.issued2008-02-04-
dc.identifier.issn0008-6215-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/133743-
dc.description.abstractThe C-1-phosphonate analogue of UDP-GlcNAc has been synthesized using an alpha-configured C-1-aldehyde as a key intermediate. Addition of the anion of diethyl phosphate to the aldehyde produced the hydroxyphosphonate. The configuration of this key intermediate was determined by X-ray crystallography. Deoxygenation, coupling of the resulting phosphonic acid with UMP and deprotection gave the target molecule as a di-sodium salt. This analogue had no detectable activity as an inhibitor of (OGT). (c) 2007 Elsevier Ltd. All rights reserved.-
dc.languageEnglish-
dc.publisherELSEVIER SCI LTD-
dc.subjectPHOSPHONATES-
dc.subjectGLUCOSAMINE-
dc.titleA convenient synthesis of the C-1-phosphonate analogue of UDP-GlcNAc and its evaluation as an inhibitor of O-linked GlcNAc transferase (OGT)-
dc.typeArticle-
dc.identifier.doi10.1016/j.carres.2007.10.027-
dc.description.journalClass1-
dc.identifier.bibliographicCitationCARBOHYDRATE RESEARCH, v.343, no.2, pp.189 - 195-
dc.citation.titleCARBOHYDRATE RESEARCH-
dc.citation.volume343-
dc.citation.number2-
dc.citation.startPage189-
dc.citation.endPage195-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.identifier.wosid000253026500003-
dc.relation.journalWebOfScienceCategoryBiochemistry & Molecular Biology-
dc.relation.journalWebOfScienceCategoryChemistry, Applied-
dc.relation.journalWebOfScienceCategoryChemistry, Organic-
dc.relation.journalResearchAreaBiochemistry & Molecular Biology-
dc.relation.journalResearchAreaChemistry-
dc.type.docTypeArticle-
dc.subject.keywordPlusPHOSPHONATES-
dc.subject.keywordPlusGLUCOSAMINE-
dc.subject.keywordAuthorO-GlcNAc transferase-
dc.subject.keywordAuthorN-acetylglucosamine-
dc.subject.keywordAuthorUDP-GlcNAc-
dc.subject.keywordAuthorphosphate isostere-
dc.subject.keywordAuthorOGT inhibition-
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