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dc.contributor.authorKwon, Hyog-Young-
dc.contributor.authorKim, Eun-Hye-
dc.contributor.authorKim, Seung-Whan-
dc.contributor.authorKim, Su-Nam-
dc.contributor.authorPark, Jong-Dae-
dc.contributor.authorRhee, Dong-Kwon-
dc.date.accessioned2024-01-21T00:00:41Z-
dc.date.available2024-01-21T00:00:41Z-
dc.date.created2021-09-03-
dc.date.issued2008-02-
dc.identifier.issn0253-6269-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/133774-
dc.description.abstractMultidrug resistance (MDR) is a major problem in cancer chemotherapy. It was previously reported that a red ginseng saponin, 20(S)-ginsenoside Rg(3) could modulate MDR in vitro and extend the survival of mice implanted with ADR-resistant murine leukemia P388 cells. This study examined the cytotoxicity of Rg3 on normal and transformed cells, along with its effect on the membrane fluidity. The cytotoxicity study revealed that 120 mu M of Rg(3) was cytotoxic against a multidrug-resistant human fibroblast carcinoma cell line, KB V20C, but not against normal WI 38 cells in vitro. Flow cytometric analysis using rhodamine 123 as the artificial substrate showed that Rg(3) promoted the accumulation of rhodamine 123 in ADR-resistant murine leukemia P388 cells in vivo. Fluorescence polarization studies using the hydrophilic fluorescent probe, DPH, and hydrophobic probe, TMA-DPH, showed that 20 mu M Rg(3) induced a significant increase in fluorescence anisotropy in KB V20C cells but not in the parental KB cells. These results clearly show that Rg(3) decreases the membrane fluidity thereby blocking drug efflux.-
dc.languageEnglish-
dc.publisherPHARMACEUTICAL SOC KOREA-
dc.subjectP-GLYCOPROTEIN-
dc.subjectPHARMACOLOGY-
dc.subjectDOXORUBICIN-
dc.subjectEXPRESSION-
dc.subjectVERAPAMIL-
dc.subjectREVERSAL-
dc.subjectPROTEIN-
dc.subjectRHODAMINE-123-
dc.subjectCONSTITUENTS-
dc.subjectBIOCHEMISTRY-
dc.titleSelective toxicity of ginsenoside Rg(3) on multidrug resistant cells by membrane fluidity modulation-
dc.typeArticle-
dc.identifier.doi10.1007/s12272-001-1137-y-
dc.description.journalClass1-
dc.identifier.bibliographicCitationARCHIVES OF PHARMACAL RESEARCH, v.31, no.2, pp.171 - 177-
dc.citation.titleARCHIVES OF PHARMACAL RESEARCH-
dc.citation.volume31-
dc.citation.number2-
dc.citation.startPage171-
dc.citation.endPage177-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.description.journalRegisteredClasskci-
dc.identifier.kciidART001244404-
dc.identifier.wosid000253582100007-
dc.identifier.scopusid2-s2.0-42949124575-
dc.relation.journalWebOfScienceCategoryChemistry, Medicinal-
dc.relation.journalWebOfScienceCategoryPharmacology & Pharmacy-
dc.relation.journalResearchAreaPharmacology & Pharmacy-
dc.type.docTypeArticle-
dc.subject.keywordPlusP-GLYCOPROTEIN-
dc.subject.keywordPlusPHARMACOLOGY-
dc.subject.keywordPlusDOXORUBICIN-
dc.subject.keywordPlusEXPRESSION-
dc.subject.keywordPlusVERAPAMIL-
dc.subject.keywordPlusREVERSAL-
dc.subject.keywordPlusPROTEIN-
dc.subject.keywordPlusRHODAMINE-123-
dc.subject.keywordPlusCONSTITUENTS-
dc.subject.keywordPlusBIOCHEMISTRY-
dc.subject.keywordAuthorPanax ginseng-
dc.subject.keywordAuthorginsenosides-
dc.subject.keywordAuthor20(S)-ginsenoside Rg(3)-
dc.subject.keywordAuthormultidrug resistance (MDR)-
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