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dc.contributor.authorByeon, Seong Rim-
dc.contributor.authorJin, Yun Jung-
dc.contributor.authorLim, Soo Jeong-
dc.contributor.authorLee, Ji Hoon-
dc.contributor.authorYoo, Kyung Ho-
dc.contributor.authorShin, Kye Jung-
dc.contributor.authorOh, Seung Jun-
dc.contributor.authorKim, Don Jin-
dc.date.accessioned2024-01-21T00:35:31Z-
dc.date.available2024-01-21T00:35:31Z-
dc.date.created2021-09-02-
dc.date.issued2007-07-15-
dc.identifier.issn0960-894X-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/134269-
dc.description.abstractNew ferulic acid and benzothiazole dimer derivatives were synthesized and evaluated by in vitro competition assay using [I-125]TZDM for their specific binding affinities to A beta fibrils. In particular, 4a showed the most excellent binding affinity (K-i = 0.53 nM), compared to PIB (K-i = 0.77 nM), for benzothiazole binding sites of A beta(1-42) fibrils. This result suggests a possibility of a potential AD diagnostic probe for detection of A beta fibrils. (C) 2007 Elsevier Ltd. All rights reserved.-
dc.languageEnglish-
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD-
dc.subjectALZHEIMERS-DISEASE-
dc.subjectALPHA-SYNUCLEIN-
dc.subjectPLAQUES-
dc.subjectPROBES-
dc.subjectHYPOTHESIS-
dc.subjectMEDICINE-
dc.titleFerulic acid and benzothiazole dimer derivatives with high binding affinity to beta-amyloid fibrils-
dc.typeArticle-
dc.identifier.doi10.1016/j.bmcl.2007.04.079-
dc.description.journalClass1-
dc.identifier.bibliographicCitationBIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.17, no.14, pp.4022 - 4025-
dc.citation.titleBIOORGANIC & MEDICINAL CHEMISTRY LETTERS-
dc.citation.volume17-
dc.citation.number14-
dc.citation.startPage4022-
dc.citation.endPage4025-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.identifier.wosid000248074600043-
dc.identifier.scopusid2-s2.0-34250674908-
dc.relation.journalWebOfScienceCategoryChemistry, Medicinal-
dc.relation.journalWebOfScienceCategoryChemistry, Organic-
dc.relation.journalResearchAreaPharmacology & Pharmacy-
dc.relation.journalResearchAreaChemistry-
dc.type.docTypeArticle-
dc.subject.keywordPlusALZHEIMERS-DISEASE-
dc.subject.keywordPlusALPHA-SYNUCLEIN-
dc.subject.keywordPlusPLAQUES-
dc.subject.keywordPlusPROBES-
dc.subject.keywordPlusHYPOTHESIS-
dc.subject.keywordPlusMEDICINE-
dc.subject.keywordAuthorferulic acid dimer-
dc.subject.keywordAuthorbenzothiazole dimer-
dc.subject.keywordAuthorA beta fibrils-
dc.subject.keywordAuthorAD diagnostic probe-
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