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dc.contributor.authorChoi, Ja Youn-
dc.contributor.authorSeo, Han Na-
dc.contributor.authorLee, Min Joo-
dc.contributor.authorPark, Seong Jun-
dc.contributor.authorPark, Sung Jun-
dc.contributor.authorJeon, Ji Young-
dc.contributor.authorKang, Joo Hi-
dc.contributor.authorPae, Ae Nim-
dc.contributor.authorRhim, Hyewhon-
dc.contributor.authorLee, Jae Yeol-
dc.date.accessioned2024-01-21T01:34:34Z-
dc.date.available2024-01-21T01:34:34Z-
dc.date.created2021-09-05-
dc.date.issued2007-01-15-
dc.identifier.issn0960-894X-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/134732-
dc.description.abstract3,4-Dihydroquinazoline analogues substituted by N-methyl-N-(5-pyrrolidinopentyl)amine at the 2-position were synthesized and their blocking effects were evaluated for T- and N-type calcium channels. Compound 11b (KYS05080), compared to mibefradil (IC50 = 1.34 0.49 mu M), was about 5-fold potent (IC50 = 0.26 +/- 0.01 mu M) for T-type calcium channel (alpha(1)G) blocking and its selectivity of T/N-type was also improved (7.5 versus 1.4 of mibefradil). (c) 2006 Elsevier Ltd. All rights reserved.-
dc.languageEnglish-
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD-
dc.subjectVOLTAGE-GATED CALCIUM-
dc.titleSynthesis and biological evaluation of novel T-type calcium channel blockers-
dc.typeArticle-
dc.identifier.doi10.1016/j.bmcl.2006.10.024-
dc.description.journalClass1-
dc.identifier.bibliographicCitationBIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.17, no.2, pp.471 - 475-
dc.citation.titleBIOORGANIC & MEDICINAL CHEMISTRY LETTERS-
dc.citation.volume17-
dc.citation.number2-
dc.citation.startPage471-
dc.citation.endPage475-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.identifier.wosid000244012200036-
dc.identifier.scopusid2-s2.0-33846054064-
dc.relation.journalWebOfScienceCategoryChemistry, Medicinal-
dc.relation.journalWebOfScienceCategoryChemistry, Organic-
dc.relation.journalResearchAreaPharmacology & Pharmacy-
dc.relation.journalResearchAreaChemistry-
dc.type.docTypeArticle-
dc.subject.keywordPlusVOLTAGE-GATED CALCIUM-
dc.subject.keywordAuthorT-type calcium channel-
dc.subject.keywordAuthorchannel blockers-
dc.subject.keywordAuthor3,4-dihydroquinazoline-
dc.subject.keywordAuthorregioisomers-
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