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dc.contributor.authorJo, Mi Na-
dc.contributor.authorSeo, Hee Jeong-
dc.contributor.authorKim, Yoonji-
dc.contributor.authorSeo, n Hee Seo-
dc.contributor.authorRhim, Hyewhon-
dc.contributor.authorCho, Yong Seo-
dc.contributor.authorCha, Joo Hwan-
dc.contributor.authorKoh, Hun Yeong-
dc.contributor.authorChoo, Hyunah-
dc.contributor.authorPae, Ae Nim-
dc.date.accessioned2024-01-21T01:34:59Z-
dc.date.available2024-01-21T01:34:59Z-
dc.date.created2021-09-05-
dc.date.issued2007-01-01-
dc.identifier.issn0968-0896-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/134749-
dc.description.abstractT-type calcium channel is one of therapeutic targets for the treatment of cardiovascular diseases and neuropathic pains. Since the withdrawal of mibefradil, a T-type calcium channel blocker, there have been a lot of efforts to develop T-type calcium channel blockers. A small molecule library of dioxoquinazoline carboxamide derivatives containing 155 compounds was designed, synthesized, and biologically evaluated for T-type calcium channel blocking activity. Among those compounds synthesized, the compound In shows the most potent T-type calcium current blocking activity with an IC50 value of 1.52 mu M, which is comparable to that of mibefradil. (c) 2006 Elsevier Ltd. All rights reserved.-
dc.languageEnglish-
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD-
dc.subjectBIOLOGICAL EVALUATION-
dc.subjectCA2+ CHANNELS-
dc.titleNovel T-type calcium channel blockers: Dioxoquinazoline carboxamide derivatives-
dc.typeArticle-
dc.identifier.doi10.1016/j.bmc.2006.09.051-
dc.description.journalClass1-
dc.identifier.bibliographicCitationBIOORGANIC & MEDICINAL CHEMISTRY, v.15, no.1, pp.365 - 373-
dc.citation.titleBIOORGANIC & MEDICINAL CHEMISTRY-
dc.citation.volume15-
dc.citation.number1-
dc.citation.startPage365-
dc.citation.endPage373-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.identifier.wosid000243087200035-
dc.identifier.scopusid2-s2.0-33750952104-
dc.relation.journalWebOfScienceCategoryBiochemistry & Molecular Biology-
dc.relation.journalWebOfScienceCategoryChemistry, Medicinal-
dc.relation.journalWebOfScienceCategoryChemistry, Organic-
dc.relation.journalResearchAreaBiochemistry & Molecular Biology-
dc.relation.journalResearchAreaPharmacology & Pharmacy-
dc.relation.journalResearchAreaChemistry-
dc.type.docTypeArticle-
dc.subject.keywordPlusBIOLOGICAL EVALUATION-
dc.subject.keywordPlusCA2+ CHANNELS-
dc.subject.keywordAuthorT-type calcium channel blockers-
dc.subject.keywordAuthordioxoquinazoline carboxamide derivatives-
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