An approach to cyclic alpha-amino acids by a novel hetero Diels-Alder/intramolecular hydantoin enolate alkylation strategy: An approach to halichlorine

Abstract

An efficient, novel synthetic strategy has been developed for preparation of cyclic alpha-amino acid employing an intermolecular hetero Diels-Alder reaction and an intramolecular hydantoin enolate alkylation as key steps. Application of the present hetero Diels-Alder/intramolecular hydantoin alkylation methodology to synthesis of halichlorine was explored.