DSpace at KISTKIST Article2006

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dc.contributor.authorKu, Il Whea-
dc.contributor.authorCho, Sangwon-
dc.contributor.authorDoddareddy, Munikumar Reddy-
dc.contributor.authorJang, Min Seok-
dc.contributor.authorKeum, Gyochang-
dc.contributor.authorLee, Jung-Ha-
dc.contributor.authorChung, Bong Young-
dc.contributor.authorKim, Youseung-
dc.contributor.authorRhim, Hyewhon-
dc.contributor.authorKang, Soon Bang-
dc.date.accessioned2024-01-21T02:05:29Z-
dc.date.available2024-01-21T02:05:29Z-
dc.date.created2021-09-01-
dc.date.issued2006-10-01-
dc.identifier.issn0960-894X-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/135036-
dc.description.abstractMorpholin-2-one-5-carboxamide derivatives were prepared by using the one-pot Ugi multicomponent reaction and evaluated for blocking effects on T- and N-type Ca2+ channels. Among them, compound 5i produced the highest potency (IC50 = 0.45 +/- 0.02 mu M), while compounds 5d, 5f, 5k, 5n, 5o, and 6m produced relatively high potency as well as selectivity on T-type Ca2+ channels. These novel scaffolds showed potent and selective T-type Ca2+ channel blocking activities. (c) 2006 Published by Elsevier Ltd.-
dc.languageEnglish-
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD-
dc.subjectCALCIUM-CHANNELS-
dc.subjectEFFICIENT SYNTHESIS-
dc.subjectIN-VITRO-
dc.subjectNEURONS-
dc.subjectPAIN-
dc.subjectDIVERSITY-
dc.subjectSUBUNITS-
dc.subjectEPILEPSY-
dc.subjectRECEPTOR-
dc.titleMorpholin-2-one derivatives as novel selective T-type Ca2+ channel blockers-
dc.typeArticle-
dc.identifier.doi10.1016/j.bmcl.2006.05.031-
dc.description.journalClass1-
dc.identifier.bibliographicCitationBIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.16, no.19, pp.5244 - 5248-
dc.citation.titleBIOORGANIC & MEDICINAL CHEMISTRY LETTERS-
dc.citation.volume16-
dc.citation.number19-
dc.citation.startPage5244-
dc.citation.endPage5248-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.identifier.wosid000240615400051-
dc.identifier.scopusid2-s2.0-33747330904-
dc.relation.journalWebOfScienceCategoryChemistry, Medicinal-
dc.relation.journalWebOfScienceCategoryChemistry, Organic-
dc.relation.journalResearchAreaPharmacology & Pharmacy-
dc.relation.journalResearchAreaChemistry-
dc.type.docTypeArticle-
dc.subject.keywordPlusCALCIUM-CHANNELS-
dc.subject.keywordPlusEFFICIENT SYNTHESIS-
dc.subject.keywordPlusIN-VITRO-
dc.subject.keywordPlusNEURONS-
dc.subject.keywordPlusPAIN-
dc.subject.keywordPlusDIVERSITY-
dc.subject.keywordPlusSUBUNITS-
dc.subject.keywordPlusEPILEPSY-
dc.subject.keywordPlusRECEPTOR-
dc.subject.keywordAuthorT-type Ca2+ channel-
dc.subject.keywordAuthormibefradil-
dc.subject.keywordAuthormorpholinone-
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