DSpace at KISTKIST Article2006

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dc.contributor.authorPark, SJ-
dc.contributor.authorPark, SJ-
dc.contributor.authorLee, MJ-
dc.contributor.authorRhim, H-
dc.contributor.authorKim, Y-
dc.contributor.authorLee, JH-
dc.contributor.authorChung, BY-
dc.contributor.authorLee, JY-
dc.date.accessioned2024-01-21T03:04:09Z-
dc.date.available2024-01-21T03:04:09Z-
dc.date.created2022-01-10-
dc.date.issued2006-05-15-
dc.identifier.issn0968-0896-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/135507-
dc.description.abstractFor the novel, potent, and selective T-type Ca2+ channel blockers, a series of sulfonamido-containing 3,4-dihydroquinazoline derivatives were prepared and evaluated for their blocking actions on T- and N-type Ca2+ channels. Among them, 9c (KYS05064, IC50 = 0.96 +/- 0.22 mu M) was found to be as potent as Mibefradil and also showed the highest selectivity for T-type Ca2+ channel with no effect on N-type Ca2+ channel. (c) 2006 Published by Elsevier Ltd.-
dc.languageEnglish-
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD-
dc.subjectIN-VITRO-
dc.subjectINHIBITION-
dc.subjectNEURONS-
dc.subjectCLONING-
dc.subjectMEMBER-
dc.titleSynthesis and SAR studies of a novel series of T-type calcium channel blockers-
dc.typeArticle-
dc.identifier.doi10.1016/j.bmc.2006.01.005-
dc.description.journalClass1-
dc.identifier.bibliographicCitationBIOORGANIC & MEDICINAL CHEMISTRY, v.14, no.10, pp.3502 - 3511-
dc.citation.titleBIOORGANIC & MEDICINAL CHEMISTRY-
dc.citation.volume14-
dc.citation.number10-
dc.citation.startPage3502-
dc.citation.endPage3511-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.identifier.wosid000236952000026-
dc.identifier.scopusid2-s2.0-33645860533-
dc.relation.journalWebOfScienceCategoryBiochemistry & Molecular Biology-
dc.relation.journalWebOfScienceCategoryChemistry, Medicinal-
dc.relation.journalWebOfScienceCategoryChemistry, Organic-
dc.relation.journalResearchAreaBiochemistry & Molecular Biology-
dc.relation.journalResearchAreaPharmacology & Pharmacy-
dc.relation.journalResearchAreaChemistry-
dc.type.docTypeArticle-
dc.subject.keywordPlusIN-VITRO-
dc.subject.keywordPlusINHIBITION-
dc.subject.keywordPlusNEURONS-
dc.subject.keywordPlusCLONING-
dc.subject.keywordPlusMEMBER-
dc.subject.keywordAuthorT-type calcium channel blockers-
dc.subject.keywordAuthorselectivity-
dc.subject.keywordAuthorpotency-
dc.subject.keywordAuthor3,4-dihydroquinazoline-
dc.subject.keywordAuthorsulfonamido group-
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