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dc.contributor.authorKim, J.-H.-
dc.contributor.authorHong, Y.-H.-
dc.contributor.authorLee, J.-H.-
dc.contributor.authorKim, D.-H.-
dc.contributor.authorNam, G.-
dc.contributor.authorJeong, S.M.-
dc.contributor.authorLee, B.-H.-
dc.contributor.authorLee, S.-M.-
dc.contributor.authorNah, S.-Y.-
dc.date.accessioned2024-01-21T05:37:13Z-
dc.date.available2024-01-21T05:37:13Z-
dc.date.created2021-09-02-
dc.date.issued2005-02-
dc.identifier.issn1016-8478-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/136806-
dc.description.abstractWe showed recently that ginsenosides inhibit the activity of various types of ion channel. Here we have investigated the role of the carbohydrate component of ginsenoside Rg3 in the inhibition of Na+ channels. The channels were expressed in Xenopus oocytes by injecting cRNAs encoding rat brain Nav1.2α and β1 subunits, and analyzed by the two-electrode voltage clamp technique. Treatment with Rg3 reversibly inhibited the inward Na+ peak current (INa) with an IC50 of 32.2 ± 4.5 μM, and the inhibition was voltage-dependent. To examine the role of the sugar moiety, we prepared a straight chain form of the second glucose and a conjugate of this glucose with 3-(4-hydroxyphenyl) propionic acid hydrazide (HPPH). Neither derivative inhibited INa. Treatment with the carbohydrate portion of ginsenoside Rg3, sophorose [β-D-glucopyranosyl (1→2)-β-glucopyranoside], or the aglycone (protopanaxadiol), on their own or in combination had no effect on I Na. These observations indicate that the carbohydrate portion of ginsenoside Rg3 plays an important role in its effect on the Na + channel. ?KSMCB 2005.-
dc.languageEnglish-
dc.publisherKOREAN SOC MOLECULAR & CELLULAR BIOLOGY-
dc.subjectaglycone-
dc.subjectcarbohydrate-
dc.subjectginsenoside Rg 3-
dc.subjectglucose-
dc.subjecthydrazide derivative-
dc.subjectprotein subunit-
dc.subjectRNA-
dc.subjectsodium channel-
dc.subjectsophorose-
dc.subjectsugar-
dc.subjectginsenoside-
dc.subjectginsenoside Rg 3-
dc.subjectglucan-
dc.subjectnerve protein-
dc.subjectprotopanaxadiol-
dc.subjectsapogenin-
dc.subjectsodium channel-
dc.subjectsodium channel, voltage gated, type II, alpha 1-
dc.subjectsodium channel, voltage-gated, type II, alpha 1-
dc.subjectsophorose-
dc.subjecttriterpene-
dc.subjectanimal cell-
dc.subjectanimal tissue-
dc.subjectarticle-
dc.subjectbrain tissue-
dc.subjectchemical structure-
dc.subjectcontrolled study-
dc.subjectdrug inhibition-
dc.subjectelectrode-
dc.subjectnonhuman-
dc.subjectoocyte-
dc.subjectrat-
dc.subjectvoltage clamp-
dc.subjectXenopus-
dc.subjectanimal-
dc.subjectchemistry-
dc.subjectdrug effect-
dc.subjectnerve cell-
dc.subjectpatch clamp-
dc.subjectphysiology-
dc.subjectstructure activity relation-
dc.subjectAnimalia-
dc.subjectAnimals-
dc.subjectGinsenosides-
dc.subjectGlucans-
dc.subjectNerve Tissue Proteins-
dc.subjectNeurons-
dc.subjectOocytes-
dc.subjectPatch-Clamp Techniques-
dc.subjectSapogenins-
dc.subjectSodium Channels-
dc.subjectStructure-Activity Relationship-
dc.subjectTriterpenes-
dc.subjectXenopus-
dc.titleA role for the carbohydrate portion of ginsenoside Rg3 in Na+ channel inhibition-
dc.typeArticle-
dc.description.journalClass1-
dc.identifier.bibliographicCitationMolecules and Cells, v.19, no.1, pp.137 - 142-
dc.citation.titleMolecules and Cells-
dc.citation.volume19-
dc.citation.number1-
dc.citation.startPage137-
dc.citation.endPage142-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.description.journalRegisteredClasskci-
dc.identifier.kciidART001189962-
dc.identifier.wosid000227439900018-
dc.identifier.scopusid2-s2.0-22844450289-
dc.relation.journalWebOfScienceCategoryBiochemistry & Molecular Biology-
dc.relation.journalWebOfScienceCategoryCell Biology-
dc.relation.journalResearchAreaBiochemistry & Molecular Biology-
dc.relation.journalResearchAreaCell Biology-
dc.type.docTypeArticle-
dc.subject.keywordPlusaglycone-
dc.subject.keywordPluscarbohydrate-
dc.subject.keywordPlusginsenoside Rg 3-
dc.subject.keywordPlusglucose-
dc.subject.keywordPlushydrazide derivative-
dc.subject.keywordPlusprotein subunit-
dc.subject.keywordPlusRNA-
dc.subject.keywordPlussodium channel-
dc.subject.keywordPlussophorose-
dc.subject.keywordPlussugar-
dc.subject.keywordPlusginsenoside-
dc.subject.keywordPlusginsenoside Rg 3-
dc.subject.keywordPlusglucan-
dc.subject.keywordPlusnerve protein-
dc.subject.keywordPlusprotopanaxadiol-
dc.subject.keywordPlussapogenin-
dc.subject.keywordPlussodium channel-
dc.subject.keywordPlussodium channel, voltage gated, type II, alpha 1-
dc.subject.keywordPlussodium channel, voltage-gated, type II, alpha 1-
dc.subject.keywordPlussophorose-
dc.subject.keywordPlustriterpene-
dc.subject.keywordPlusanimal cell-
dc.subject.keywordPlusanimal tissue-
dc.subject.keywordPlusarticle-
dc.subject.keywordPlusbrain tissue-
dc.subject.keywordPluschemical structure-
dc.subject.keywordPluscontrolled study-
dc.subject.keywordPlusdrug inhibition-
dc.subject.keywordPluselectrode-
dc.subject.keywordPlusnonhuman-
dc.subject.keywordPlusoocyte-
dc.subject.keywordPlusrat-
dc.subject.keywordPlusvoltage clamp-
dc.subject.keywordPlusXenopus-
dc.subject.keywordPlusanimal-
dc.subject.keywordPluschemistry-
dc.subject.keywordPlusdrug effect-
dc.subject.keywordPlusnerve cell-
dc.subject.keywordPluspatch clamp-
dc.subject.keywordPlusphysiology-
dc.subject.keywordPlusstructure activity relation-
dc.subject.keywordPlusAnimalia-
dc.subject.keywordPlusAnimals-
dc.subject.keywordPlusGinsenosides-
dc.subject.keywordPlusGlucans-
dc.subject.keywordPlusNerve Tissue Proteins-
dc.subject.keywordPlusNeurons-
dc.subject.keywordPlusOocytes-
dc.subject.keywordPlusPatch-Clamp Techniques-
dc.subject.keywordPlusSapogenins-
dc.subject.keywordPlusSodium Channels-
dc.subject.keywordPlusStructure-Activity Relationship-
dc.subject.keywordPlusTriterpenes-
dc.subject.keywordPlusXenopus-
dc.subject.keywordAuthorAglycone-
dc.subject.keywordAuthorBrain Na+ Channel-
dc.subject.keywordAuthorCarbohydrate Portion-
dc.subject.keywordAuthorGinsenoside Rg3-
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