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dc.contributor.authorRhim, H-
dc.contributor.authorLee, YS-
dc.contributor.authorPark, SJ-
dc.contributor.authorChung, BY-
dc.contributor.authorLee, JY-
dc.date.accessioned2024-01-21T05:38:07Z-
dc.date.available2024-01-21T05:38:07Z-
dc.date.created2021-09-03-
dc.date.issued2005-01-17-
dc.identifier.issn0960-894X-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/136822-
dc.description.abstractWe have synthesized 3,4-dihydroquinazoline derivatives for the potent and selective T-type Ca2+ channel blockers and evaluated for their inhibitory activities against two subtypes T-type Ca2+ channels and N-type Ca2+ channels. Among them, 5b (KYS05044, IC50 = 0.56 +/- 0.10 muM) was identified as potent T-type Ca2+ channel blocker with in vitro selectivity profile at meaningful level (T/N-type, SI = >100). (C) 2004 Elsevier Ltd. All rights reserved.-
dc.languageEnglish-
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD-
dc.subjectIN-VITRO-
dc.subjectPHARMACOLOGICAL-PROPERTIES-
dc.subjectCALCIUM-
dc.subjectINHIBITION-
dc.subjectMIBEFRADIL-
dc.subjectNEURONS-
dc.subjectCLONING-
dc.subjectMEMBER-
dc.subjectACID-
dc.subjectPAIN-
dc.titleSynthesis and biological activity of 3,4-dihydroquinazolines for selective T-type Ca2+ channel blockers-
dc.typeArticle-
dc.identifier.doi10.1016/j.bmcl.2004.10.078-
dc.description.journalClass1-
dc.identifier.bibliographicCitationBIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.15, no.2, pp.283 - 286-
dc.citation.titleBIOORGANIC & MEDICINAL CHEMISTRY LETTERS-
dc.citation.volume15-
dc.citation.number2-
dc.citation.startPage283-
dc.citation.endPage286-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.identifier.wosid000226344800008-
dc.identifier.scopusid2-s2.0-10644273394-
dc.relation.journalWebOfScienceCategoryChemistry, Medicinal-
dc.relation.journalWebOfScienceCategoryChemistry, Organic-
dc.relation.journalResearchAreaPharmacology & Pharmacy-
dc.relation.journalResearchAreaChemistry-
dc.type.docTypeArticle-
dc.subject.keywordPlusIN-VITRO-
dc.subject.keywordPlusPHARMACOLOGICAL-PROPERTIES-
dc.subject.keywordPlusCALCIUM-
dc.subject.keywordPlusINHIBITION-
dc.subject.keywordPlusMIBEFRADIL-
dc.subject.keywordPlusNEURONS-
dc.subject.keywordPlusCLONING-
dc.subject.keywordPlusMEMBER-
dc.subject.keywordPlusACID-
dc.subject.keywordPlusPAIN-
dc.subject.keywordAuthorT-type Ca2+ channel-
dc.subject.keywordAuthormibefradil-
dc.subject.keywordAuthor3,4-dihydroquinazolines-
dc.subject.keywordAuthorchannel selectivity-
dc.subject.keywordAuthorblockers-
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