Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Oh, CH | - |
dc.contributor.author | Hong, JH | - |
dc.date.accessioned | 2024-01-21T06:39:01Z | - |
dc.date.available | 2024-01-21T06:39:01Z | - |
dc.date.created | 2021-09-04 | - |
dc.date.issued | 2004-08 | - |
dc.identifier.issn | 0365-6233 | - |
dc.identifier.uri | https://pubs.kist.re.kr/handle/201004/137375 | - |
dc.description.abstract | In this study, a series of 2',4-' or 3',4'-doubly branched carbocyclic nucleosides (11, 12, 19, and 20) were synthesized from simple acyclic ketone derivatives as starting materials. The installation of the 4'-quaternary carbon needed was carried out using a [3,3]-sigmatropic rearrangement. In addition, the introduction of a methyl group in the 2'- or 3'-position was accomplished by either Grignard reaction or Horner-Wadsworth-Emmons reaction with triethyl-2-phosphonopropionate, respectively. Bis-vinyl was successfully cyclized using a Grubbs' catalyst II. The natural bases (adenine, cytosine) were coupled efficiently using a Pd(O) catalyst. Although all the synthesized compounds were assayed against several viruses, only the cytosine analogue 20 showed moderate antiviral activity against the human cytomegalovirus. | - |
dc.language | English | - |
dc.publisher | WILEY-V C H VERLAG GMBH | - |
dc.subject | HUMAN-IMMUNODEFICIENCY-VIRUS | - |
dc.subject | HEPATITIS-B-VIRUS | - |
dc.subject | S-ADENOSYLHOMOCYSTEINE | - |
dc.subject | EFFICIENT SYNTHESIS | - |
dc.subject | CLOSING METATHESIS | - |
dc.subject | REPLICATION | - |
dc.subject | ANALOGS | - |
dc.title | Synthesis and antiviral activities of novel 2 ',4 '- or 3 ',4 '-doubly branched carbocyclic nucleosides as potential antiviral agents | - |
dc.type | Article | - |
dc.identifier.doi | 10.1002/ardp.200400875 | - |
dc.description.journalClass | 1 | - |
dc.identifier.bibliographicCitation | ARCHIV DER PHARMAZIE, v.337, no.8, pp.457 - 463 | - |
dc.citation.title | ARCHIV DER PHARMAZIE | - |
dc.citation.volume | 337 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 457 | - |
dc.citation.endPage | 463 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.identifier.wosid | 000223437900006 | - |
dc.identifier.scopusid | 2-s2.0-4544348663 | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | HUMAN-IMMUNODEFICIENCY-VIRUS | - |
dc.subject.keywordPlus | HEPATITIS-B-VIRUS | - |
dc.subject.keywordPlus | S-ADENOSYLHOMOCYSTEINE | - |
dc.subject.keywordPlus | EFFICIENT SYNTHESIS | - |
dc.subject.keywordPlus | CLOSING METATHESIS | - |
dc.subject.keywordPlus | REPLICATION | - |
dc.subject.keywordPlus | ANALOGS | - |
dc.subject.keywordAuthor | carbocyclic nucleosides | - |
dc.subject.keywordAuthor | [3,3]-sigmatropic rearrangement | - |
dc.subject.keywordAuthor | Horner-Wadsworth-Emmons reaction | - |
dc.subject.keywordAuthor | antiviral agents | - |
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