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dc.contributor.authorLee, YS-
dc.contributor.authorLee, BH-
dc.contributor.authorPark, SJ-
dc.contributor.authorKang, SB-
dc.contributor.authorRhim, H-
dc.contributor.authorPark, JY-
dc.contributor.authorLee, JH-
dc.contributor.authorJeong, SW-
dc.contributor.authorLee, JY-
dc.date.accessioned2024-01-21T06:41:07Z-
dc.date.available2024-01-21T06:41:07Z-
dc.date.created2021-09-05-
dc.date.issued2004-07-05-
dc.identifier.issn0960-894X-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/137413-
dc.description.abstractFor LVA T-type Ca2+ channel blockers, 3,4-dihydroquinazoline derivatives as new scaffolds were prepared and evaluated for the inhibitory activity against two members of the recombinant T-type Ca2+ channel family. Among them, 8a (KYS05001, IC50 = 0-9 muM) was nearly equipotent with mibefradil (IC50 = 0.84 muM) and inhibited LVA T-type Ca2+ channel with greater efficacy than HVA Ca2+ channel. (C) 2004 Elsevier Ltd. All rights reserved.-
dc.languageEnglish-
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD-
dc.subjectCALCIUM-CHANNELS-
dc.subjectPHARMACOLOGICAL-PROPERTIES-
dc.subjectTHALAMIC NEURONS-
dc.subjectIN-VITRO-
dc.subjectCARBODIIMIDE-
dc.subjectMIBEFRADIL-
dc.subjectINHIBITION-
dc.subjectTHRESHOLD-
dc.subjectALPHA-1H-
dc.subjectCONDUCTANCES-
dc.title3,4-dihydroquinazoline derivatives as novel selective T-type Ca2+ channel blockers-
dc.typeArticle-
dc.identifier.doi10.1016/j.bmcl.2004.04.090-
dc.description.journalClass1-
dc.identifier.bibliographicCitationBIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.14, no.13, pp.3379 - 3384-
dc.citation.titleBIOORGANIC & MEDICINAL CHEMISTRY LETTERS-
dc.citation.volume14-
dc.citation.number13-
dc.citation.startPage3379-
dc.citation.endPage3384-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.identifier.wosid000221998100001-
dc.identifier.scopusid2-s2.0-2942531077-
dc.relation.journalWebOfScienceCategoryChemistry, Medicinal-
dc.relation.journalWebOfScienceCategoryChemistry, Organic-
dc.relation.journalResearchAreaPharmacology & Pharmacy-
dc.relation.journalResearchAreaChemistry-
dc.type.docTypeArticle-
dc.subject.keywordPlusCALCIUM-CHANNELS-
dc.subject.keywordPlusPHARMACOLOGICAL-PROPERTIES-
dc.subject.keywordPlusTHALAMIC NEURONS-
dc.subject.keywordPlusIN-VITRO-
dc.subject.keywordPlusCARBODIIMIDE-
dc.subject.keywordPlusMIBEFRADIL-
dc.subject.keywordPlusINHIBITION-
dc.subject.keywordPlusTHRESHOLD-
dc.subject.keywordPlusALPHA-1H-
dc.subject.keywordPlusCONDUCTANCES-
dc.subject.keywordAuthor3,4-dihydroquinazolines-
dc.subject.keywordAuthorT-type calcium channel-
dc.subject.keywordAuthorblockers-
dc.subject.keywordAuthormibefradil-
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