Synthesis of 2-substituted 3,4-dihydroquinazoline derivatives via regioselective addition of a carbon nucleophile to a carbodiimide

Abstract

Synthesis of 2-alkyl or phenyl-substituted 3,4-dihydroquinazoline derivatives (6) is described via regioselective carbon nucleophilic addition (RMgBr and RM) to a carbodiimide (4) followed by intramolecular conjugate addition.