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dc.contributor.authorPae, AN-
dc.contributor.authorLee, JE-
dc.contributor.authorKim, BH-
dc.contributor.authorCha, JH-
dc.contributor.authorKim, HY-
dc.contributor.authorCho, YS-
dc.contributor.authorChoi, KI-
dc.contributor.authorKoh, HY-
dc.contributor.authorLee, E-
dc.contributor.authorKim, JH-
dc.date.accessioned2024-01-21T13:41:25Z-
dc.date.available2024-01-21T13:41:25Z-
dc.date.created2021-09-05-
dc.date.issued2000-07-28-
dc.identifier.issn0040-4020-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/141223-
dc.description.abstractStructural modifications and biological evaluations of 3-isoxazolylvinylcephalosporins (I) were performed. The replacement of a hydrogen atom at the 7-aminothiazole group by a chlorine resulted in an improvement: of the activity against resistant Gram-positive bacterial strains including the methicillin-resistant Staphylococcus aureus (MRSA) and the ciprofloxacin-resistant Staphylococcus aureus (CRSA). The introduction of other heterocycles such as an isothiazole or a thiadiazole in place of the isoxazole moiety gave slightly decreased in vitro activities. (C) 2000 Elsevier Science Ltd. All rights reserved.-
dc.languageEnglish-
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD-
dc.subjectCATECHOL MOIETY-
dc.subjectC-7 POSITION-
dc.subjectCEPHALOSPORINS-
dc.subjectDERIVATIVES-
dc.titleStructural modifications and biological evaluation of 3-isoxazolylvinylcephalosporins-
dc.typeArticle-
dc.identifier.doi10.1016/S0040-4020(00)00415-4-
dc.description.journalClass1-
dc.identifier.bibliographicCitationTETRAHEDRON, v.56, no.31, pp.5657 - 5665-
dc.citation.titleTETRAHEDRON-
dc.citation.volume56-
dc.citation.number31-
dc.citation.startPage5657-
dc.citation.endPage5665-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.identifier.wosid000088474500012-
dc.identifier.scopusid2-s2.0-0001033677-
dc.relation.journalWebOfScienceCategoryChemistry, Organic-
dc.relation.journalResearchAreaChemistry-
dc.type.docTypeArticle-
dc.subject.keywordPlusCATECHOL MOIETY-
dc.subject.keywordPlusC-7 POSITION-
dc.subject.keywordPlusCEPHALOSPORINS-
dc.subject.keywordPlusDERIVATIVES-
dc.subject.keywordAuthorantibacterials-
dc.subject.keywordAuthorcephalosporins-
dc.subject.keywordAuthorisoxazoles-
dc.subject.keywordAuthorthiazoles-
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