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Syntheses and binding affinities of 6-nitroquipazine analogues for serotonin transporter. Part 1

Authors: Lee, BS; Chu, S; Lee, BC; Chi, DY; Choe, YS; Jeong, KJ; Jin, C

Issue Date: 2000-07-17

Publisher: PERGAMON-ELSEVIER SCIENCE LTD

Citation: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.10, no.14, pp.1559 - 1562

Abstract: 6-Nitroquipazine has been known as one of the most potent and selective inhibitors of serotonin transporter in vitro and in vivo. Nine derivatives of 6-nitroquipazine were synthesized and tested for their potential abilities to displace [H-3]citalopram binding to the rat cortical membranes. (C) 2000 Elsevier Science Ltd. All rights reserved.

Keywords: 5-HYDROXYTRYPTAMINE UPTAKE COMPLEX; DIFFERENT INTRINSIC EFFICACY; I-125 5-IODO-6-NITROQUIPAZINE; ARYLPIPERAZINE DERIVATIVES; H-3 6-NITROQUIPAZINE; SELECTIVE LIGAND; UPTAKE SITES; POTENT; RAT; INHIBITION; 5-HYDROXYTRYPTAMINE UPTAKE COMPLEX; DIFFERENT INTRINSIC EFFICACY; I-125 5-IODO-6-NITROQUIPAZINE; ARYLPIPERAZINE DERIVATIVES; H-3 6-NITROQUIPAZINE; SELECTIVE LIGAND; UPTAKE SITES; POTENT; RAT; INHIBITION; 6-nitroquipazine

ISSN: 0960-894X

URI: https://pubs.kist.re.kr/handle/201004/141225

DOI: 10.1016/S0960-894X(00)00290-0

Appears in Collections:: KIST Article > 2000

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