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dc.contributor.authorKim, SH-
dc.contributor.authorKatzenellenbogen, JA-
dc.date.accessioned2024-01-21T14:11:18Z-
dc.date.available2024-01-21T14:11:18Z-
dc.date.created2021-09-04-
dc.date.issued2000-04-
dc.identifier.issn0968-0896-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/141493-
dc.description.abstractWe have prepared a series of triarylethylene and triarylethane systems, analogues of the selective antiestrogen tamoxifen, in which the alkyl substituent is tethered to the distal, rather than the proximal aryl ring by a 5-, 6-, or 7-membered carbocycle. This unusual cyclic structure rigidifies the ligand and adds bulk in a manner that is different from the more typical cyclization to the proximal aryl ring, as in the antiestrogen nafoxidine. These new systems were prepared efficiently by the addition of a benzylic sodium reagent, generated fi om the corresponding chloride by treatment with sodium naphthalenide, to a doubly protected 4,4'-dihydroxybenzophenone, followed by dehydration and deprotection. In all cases, formation of the exocyclic alkene was preferred. Two of the corresponding alkanes could be obtained by catalytic hydrogenation. All of these compounds have relatively high binding affinity for the estrogen receptor, and some of them demonstrate a significant level of affinity selectivity for the estrogen receptor alpha subtype. Accommodation of these newly rigidified cyclic triarylethylene systems into the ligand-binding pocket of the estrogen receptor can be visualized by molecular modeling. (C) 2000 Elsevier Science Ltd. All rights reserved.-
dc.languageEnglish-
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD-
dc.subjectBINDING-AFFINITY-
dc.subjectBREAST-CANCER-
dc.subjectANTIESTROGENS-
dc.subjectTAMOXIFEN-
dc.subjectANTAGONIST-
dc.titleTriarylethylene bisphenols with a novel cycle are ligands for the estrogen receptor-
dc.typeArticle-
dc.identifier.doi10.1016/S0968-0896(00)00016-X-
dc.description.journalClass1-
dc.identifier.bibliographicCitationBIOORGANIC & MEDICINAL CHEMISTRY, v.8, no.4, pp.785 - 793-
dc.citation.titleBIOORGANIC & MEDICINAL CHEMISTRY-
dc.citation.volume8-
dc.citation.number4-
dc.citation.startPage785-
dc.citation.endPage793-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.identifier.wosid000086862200012-
dc.identifier.scopusid2-s2.0-0034067895-
dc.relation.journalWebOfScienceCategoryBiochemistry & Molecular Biology-
dc.relation.journalWebOfScienceCategoryChemistry, Medicinal-
dc.relation.journalWebOfScienceCategoryChemistry, Organic-
dc.relation.journalResearchAreaBiochemistry & Molecular Biology-
dc.relation.journalResearchAreaPharmacology & Pharmacy-
dc.relation.journalResearchAreaChemistry-
dc.type.docTypeArticle-
dc.subject.keywordPlusBINDING-AFFINITY-
dc.subject.keywordPlusBREAST-CANCER-
dc.subject.keywordPlusANTIESTROGENS-
dc.subject.keywordPlusTAMOXIFEN-
dc.subject.keywordPlusANTAGONIST-
dc.subject.keywordAuthorestrogen receptor-
dc.subject.keywordAuthorTriarylethylene bisphenol-
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KIST Article > 2000
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