Artificial keloid skin models: understanding the pathophysiological mechanisms and application in therapeutic studies

Authors
Kwon, Soo hyunLee, JongminYoo, JinJung, Youngmee
Issue Date
2024-07
Publisher
Royal Society of Chemistry
Citation
Biomaterials Science, v.12, no.13, pp.3321 - 3334
Abstract
Keloid is a type of scar formed by the overexpression of extracellular matrix substances from fibroblasts following inflammation after trauma. The existing keloid treatment methods include drug injection, surgical intervention, light exposure, cryotherapy, etc. However, these methods have limitations such as recurrence, low treatment efficacy, and side effects. Consequently, studies are being conducted on the treatment of keloids from the perspective of inflammatory mechanisms. In this study, keloid models are created to understand inflammatory mechanisms and explore treatment methods to address them. While previous studies have used animal models with gene mutations, chemical treatments, and keloid tissue transplantation, there are limitations in fully reproducing the characteristics of keloids unique to humans, and ethical issues related to animal welfare pose additional challenges. Consequently, studies are underway to create in vitro artificial skin models to simulate keloid disease and apply them to the development of treatments for skin diseases. In particular, herein, scaffold technologies that implement three-dimensional (3D) full-thickness keloid models are introduced to enhance mechanical properties as well as biological properties of tissues, such as cell proliferation, differentiation, and cellular interactions. It is anticipated that applying these technologies to the production of artificial skin for keloid simulation could contribute to the development of inflammatory keloid treatment techniques in the future. Keloid is a type of scar formed by the overexpression of extracellular matrix substances from fibroblasts following inflammation after trauma.
Keywords
HYPERTROPHIC SCAR MODEL; PULSED-DYE-LASER; 2 MICE EXHIBIT; ANIMAL-MODEL; RABBIT EAR; EXTRACELLULAR-MATRIX; MURINE MODEL; INTRALESIONAL CRYOSURGERY; CUTANEOUS FIBROSIS; SYSTEMIC-SCLEROSIS
ISSN
2047-4830
URI
https://pubs.kist.re.kr/handle/201004/150066
DOI
10.1039/d4bm00005f
Appears in Collections:
KIST Article > 2024
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