Cannabidiol (CBD) 및 Δ9-Tetrahydrocannabinol (THC) 생산을 위한 헴프 추출물의 신규 가공법 개발

Abstract

The global industrial hemp market is rapidly expanding, driven by the growing demand for cannabinoids such as CBD and THC, highlighting the need for efficient production technologies. This study optimized CBD and THC production by combining dielectric heating-based microwave technology with a continuous process. For CBD production via CBDA decarboxylation in hemp extracts, the continuous process achieved a higher yield (92.8%) under milder conditions (90°C for 30 min) compared to the batch process (90.3% at 120°C for 30 min). Similarly, for THC production via CBD cyclization in hemp extracts, the continuous process yielded 70.5% under shorter reaction times (80°C for 10 min with HCl) compared to 62.1% in the batch process (80°C for 20 min with p-toluenesulfonic acid). These results demonstrate that continuous microwave processing is an efficient and scalable technology for cannabinoid production, supporting the growth of the global industrial hemp market.