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dc.contributor.authorKim, Dongwoo-
dc.contributor.authorChun, Joong Hyun-
dc.contributor.authorYi, Ju Hyeon-
dc.contributor.authorKo, Hae Young-
dc.contributor.authorChung, Jee-In-
dc.contributor.authorLee, Misu-
dc.contributor.authorPark, Yongmin Mason-
dc.contributor.authorNam, Min-Ho-
dc.contributor.authorKim, Jisu-
dc.contributor.authorKim, Seon Yoo-
dc.contributor.authorPark, Youngjoo-
dc.contributor.authorMoon, Ju Hyung-
dc.contributor.authorKang, Seok-Gu-
dc.contributor.authorChang, Jong Hee-
dc.contributor.authorLee, C. Justin-
dc.contributor.authorKim, Se Hoon-
dc.contributor.authorYun, Mijin-
dc.date.accessioned2024-01-12T02:37:01Z-
dc.date.available2024-01-12T02:37:01Z-
dc.date.created2022-08-02-
dc.date.issued2022-10-
dc.identifier.issn0363-9762-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/76007-
dc.description.abstractPurpose C-11-acetate (C-11-ACE) uptake on PET/CT was recently discovered to represent reactive astrocytes in the tumor microenvironment. This study aimed at evaluating the role of C-11-ACE PET/CT as an imaging biomarker of reactive astrogliosis in characterizing different types of gliomas. Methods In this prospective study, a total of 182 patients underwent C-11-ACE PET/CT before surgery. The ratio of SUVmax of a glioma to the SUVmean of the contralateral choroid plexus (C-11-ACE TCR) on PET/CT was calculated. C-11-ACE TCRs were compared with the World Health Organization grades and isocitrate dehydrogenase 1 (IDH1) mutation status. Grade 2 was considered low-grade tumor, and grades 3 and 4 were considered high-grade tumors. Results The median C-11-ACE TCR was significantly higher in IDH1 wild-type (wt) tumors (n = 91) than in IDH1-mutant (mt) tumors (n = 91) (2.38 vs 1.30, P < 0.001). Of the 91 IDH1-mt tumors, there were no differences in the median C-11-ACE TCRs between oligodendrogliomas (ODs) and astrocytic tumors (1.40 vs 1.20, P > 0.05). In grading low- versus high-grade gliomas, the receiver operating characteristic curve analyses showed a higher area under the curve (0.951) in IDH1-wt tumors than in IDH1-mt tumors (0.783, P = 0.002). Grade 2 ODs were well differentiated from high-grade gliomas. The C-11-ACE TCR of grade 3 ODs was significantly lower than that of IDH1-wt glioblastomas. Conclusions High C-11-ACE uptake is associated with high-grade IDH1-wt tumors, thus facilitating differentiation from high-grade IDH1-mt and low-grade gliomas. In particular, low C-11-ACE uptake in ODs is advantageous in overcoming the limitation of radiolabeled amino acid tracers.-
dc.languageEnglish-
dc.publisherLippincott Williams & Wilkins Ltd.-
dc.title11C-Acetate PET/CT Detects Reactive Astrogliosis Helping Glioma Classification-
dc.typeArticle-
dc.identifier.doi10.1097/RLU.0000000000004341-
dc.description.journalClass1-
dc.identifier.bibliographicCitationClinical Nuclear Medicine, v.47, no.10, pp.863 - 868-
dc.citation.titleClinical Nuclear Medicine-
dc.citation.volume47-
dc.citation.number10-
dc.citation.startPage863-
dc.citation.endPage868-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.identifier.wosid000850302800025-
dc.relation.journalWebOfScienceCategoryRadiology, Nuclear Medicine & Medical Imaging-
dc.relation.journalResearchAreaRadiology, Nuclear Medicine & Medical Imaging-
dc.type.docTypeArticle-
dc.subject.keywordPlusBRAIN GLIOMA-
dc.subject.keywordPlusC-11-METHIONINE-
dc.subject.keywordPlusASTROCYTES-
dc.subject.keywordPlusSURVIVAL-
dc.subject.keywordPlusTUMORS-
dc.subject.keywordAuthorC-11-acetate PET-
dc.subject.keywordAuthorCT-
dc.subject.keywordAuthorglioma-
dc.subject.keywordAuthorgrading-
dc.subject.keywordAuthorIDH1 mutation-
dc.subject.keywordAuthorreactive astrogliosis-
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