Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Dongwoo | - |
dc.contributor.author | Chun, Joong Hyun | - |
dc.contributor.author | Yi, Ju Hyeon | - |
dc.contributor.author | Ko, Hae Young | - |
dc.contributor.author | Chung, Jee-In | - |
dc.contributor.author | Lee, Misu | - |
dc.contributor.author | Park, Yongmin Mason | - |
dc.contributor.author | Nam, Min-Ho | - |
dc.contributor.author | Kim, Jisu | - |
dc.contributor.author | Kim, Seon Yoo | - |
dc.contributor.author | Park, Youngjoo | - |
dc.contributor.author | Moon, Ju Hyung | - |
dc.contributor.author | Kang, Seok-Gu | - |
dc.contributor.author | Chang, Jong Hee | - |
dc.contributor.author | Lee, C. Justin | - |
dc.contributor.author | Kim, Se Hoon | - |
dc.contributor.author | Yun, Mijin | - |
dc.date.accessioned | 2024-01-12T02:37:01Z | - |
dc.date.available | 2024-01-12T02:37:01Z | - |
dc.date.created | 2022-08-02 | - |
dc.date.issued | 2022-10 | - |
dc.identifier.issn | 0363-9762 | - |
dc.identifier.uri | https://pubs.kist.re.kr/handle/201004/76007 | - |
dc.description.abstract | Purpose C-11-acetate (C-11-ACE) uptake on PET/CT was recently discovered to represent reactive astrocytes in the tumor microenvironment. This study aimed at evaluating the role of C-11-ACE PET/CT as an imaging biomarker of reactive astrogliosis in characterizing different types of gliomas. Methods In this prospective study, a total of 182 patients underwent C-11-ACE PET/CT before surgery. The ratio of SUVmax of a glioma to the SUVmean of the contralateral choroid plexus (C-11-ACE TCR) on PET/CT was calculated. C-11-ACE TCRs were compared with the World Health Organization grades and isocitrate dehydrogenase 1 (IDH1) mutation status. Grade 2 was considered low-grade tumor, and grades 3 and 4 were considered high-grade tumors. Results The median C-11-ACE TCR was significantly higher in IDH1 wild-type (wt) tumors (n = 91) than in IDH1-mutant (mt) tumors (n = 91) (2.38 vs 1.30, P < 0.001). Of the 91 IDH1-mt tumors, there were no differences in the median C-11-ACE TCRs between oligodendrogliomas (ODs) and astrocytic tumors (1.40 vs 1.20, P > 0.05). In grading low- versus high-grade gliomas, the receiver operating characteristic curve analyses showed a higher area under the curve (0.951) in IDH1-wt tumors than in IDH1-mt tumors (0.783, P = 0.002). Grade 2 ODs were well differentiated from high-grade gliomas. The C-11-ACE TCR of grade 3 ODs was significantly lower than that of IDH1-wt glioblastomas. Conclusions High C-11-ACE uptake is associated with high-grade IDH1-wt tumors, thus facilitating differentiation from high-grade IDH1-mt and low-grade gliomas. In particular, low C-11-ACE uptake in ODs is advantageous in overcoming the limitation of radiolabeled amino acid tracers. | - |
dc.language | English | - |
dc.publisher | Lippincott Williams & Wilkins Ltd. | - |
dc.title | 11C-Acetate PET/CT Detects Reactive Astrogliosis Helping Glioma Classification | - |
dc.type | Article | - |
dc.identifier.doi | 10.1097/RLU.0000000000004341 | - |
dc.description.journalClass | 1 | - |
dc.identifier.bibliographicCitation | Clinical Nuclear Medicine, v.47, no.10, pp.863 - 868 | - |
dc.citation.title | Clinical Nuclear Medicine | - |
dc.citation.volume | 47 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 863 | - |
dc.citation.endPage | 868 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.identifier.wosid | 000850302800025 | - |
dc.relation.journalWebOfScienceCategory | Radiology, Nuclear Medicine & Medical Imaging | - |
dc.relation.journalResearchArea | Radiology, Nuclear Medicine & Medical Imaging | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | BRAIN GLIOMA | - |
dc.subject.keywordPlus | C-11-METHIONINE | - |
dc.subject.keywordPlus | ASTROCYTES | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordPlus | TUMORS | - |
dc.subject.keywordAuthor | C-11-acetate PET | - |
dc.subject.keywordAuthor | CT | - |
dc.subject.keywordAuthor | glioma | - |
dc.subject.keywordAuthor | grading | - |
dc.subject.keywordAuthor | IDH1 mutation | - |
dc.subject.keywordAuthor | reactive astrogliosis | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.