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dc.contributor.authorKwon, Jaeyoung-
dc.contributor.authorLee, Kyerim-
dc.contributor.authorHwang, Ho Seong-
dc.contributor.authorSeong-Hwan Kim-
dc.contributor.authorPark, Se Eun-
dc.contributor.authorDurai, Prasannavenkatesh-
dc.contributor.authorPark, Keun wan-
dc.contributor.authorKim, Hyung-Seop-
dc.contributor.authorJang, Dae Sik-
dc.contributor.authorChoi, Jae Sue-
dc.contributor.authorKwon, Hak Cheol-
dc.date.accessioned2024-01-12T03:00:56Z-
dc.date.available2024-01-12T03:00:56Z-
dc.date.created2022-08-09-
dc.date.issued2022-08-
dc.identifier.issn2223-7747-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/76645-
dc.description.abstractAlgae are unique natural products that can produce various types of biologically active compounds. The 70% ethanol extract of brown algae Sargassum macrocarpum collected from the East Sea of Korea inhibited human monoamine oxidases A and B enzymes (hMAO-A and hMAO-B) at a 50 μg/mL concentration. The bioassay-guided isolation was performed through solid-phase extraction and the Sepbox system followed by serial high-performance liquid chromatography on the reverse phase condition, resulting in the identification of two new monocyclic terpenoid lactones, sargassumins A and B (1 and 2). The planar structures of the compounds were determined by a combination of spectroscopic data. The absolute configurations were determined by the interpretation of circular dichroism data. Compound 1 exhibited mild hMAO-A inhibition (42.18 ± 2.68% at 200 μM) and docked computationally into the active site of hMAO-A (?8.48 kcal/mol). Although compound 2 could not be tested due to insufficient quantity, it docked better into hMAO-A (?9.72 kcal/mol). Therefore, the above results suggest that this type of monocyclic terpenoid lactone could be one of the potential lead compounds for the treatment of psychiatric or neurological diseases.-
dc.languageEnglish-
dc.publisherMDPI AG-
dc.titleNew Monocyclic Terpenoid Lactones from a Brown Algae Sargassum macrocarpum as Monoamine Oxidase Inhibitors-
dc.typeArticle-
dc.identifier.doi10.3390/plants11151998-
dc.description.journalClass1-
dc.identifier.bibliographicCitationPlants, v.11, no.15, pp.1998-
dc.citation.titlePlants-
dc.citation.volume11-
dc.citation.number15-
dc.citation.startPage1998-
dc.description.isOpenAccessY-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.identifier.wosid000840218300001-
dc.relation.journalWebOfScienceCategoryPlant Sciences-
dc.relation.journalResearchAreaPlant Sciences-
dc.type.docTypeArticle-
dc.subject.keywordAuthorSargassum macrocarpum-
dc.subject.keywordAuthorterpenoids-
dc.subject.keywordAuthorSepbox-
dc.subject.keywordAuthorMAO enzyme inhibitor-
dc.subject.keywordAuthormolecular docking-
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