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dc.contributor.authorJun Hee Kim-
dc.contributor.authorHan, Young-Eun-
dc.contributor.authorOh, Soo-Jin-
dc.contributor.authorLee, Bonggi-
dc.contributor.authorKwon, Obin-
dc.contributor.authorChoi, Chun Whan-
dc.contributor.authorKim, Min Soo-
dc.date.accessioned2024-01-12T06:35:01Z-
dc.date.available2024-01-12T06:35:01Z-
dc.date.created2023-08-04-
dc.date.issued2023-07-
dc.identifier.issn2045-2322-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/79873-
dc.description.abstractNeurodegenerative diseases are explained by progressive defects of cognitive function and memory. These defects of cognition and memory dysfunction can be induced by the loss of brain-derived neurotrophic factors (BDNF) signaling. Paeonia lactiflora is a traditionally used medicinal herb in Asian countries and some beneficial effects have been reported, including anti-oxidative, anti-inflammatory, anti-cancer activity, and potential neuroprotective effects recently. In this study, we found that suffruticosol A is a major compound in seeds of Paeonia lactiflora. When treated in a SH-SY5 cell line for measuring cell viability and cell survival, suffruticosol A increased cell viability (at 20 ?M) and recovered scopolamine-induced neurodegenerative characteristics in the cells. To further confirm its neural amelioration effects in the animals, suffruticosol A (4 or 15 ng, twice a week) was administered into the third ventricle beside the brain of C57BL/6 mice for one month then the scopolamine was intraperitoneally injected into these mice to induce impairments of cognition and memory before conducting behavioral experiments. Central administration of suffruticosol A into the brain restored the memory and cognition behaviors in mice that received the scopolamine. Consistently, the central treatments of suffruticosol A showed rescued cholinergic deficits and BDNF signaling in the hippocampus of mice. Finally, we measured the long-term potentiation (LTP) in the hippocampal CA3?CA1 synapse to figure out the restoration of the synaptic mechanism of learning and memory. Bath application of suffruticosol A (40 ?M) improved LTP impairment induced by scopolamine in hippocampal slices. In conclusion, the central administration of suffruticosol A ameliorated neuronal effects partly through elevated BDNF signaling.-
dc.languageEnglish-
dc.publisherNature Publishing Group-
dc.titleEnhanced neuronal activity by suffruticosol A extracted from Paeonia lactiflora via partly BDNF signaling in scopolamine-induced memory-impaired mice-
dc.typeArticle-
dc.identifier.doi10.1038/s41598-023-38773-8-
dc.description.journalClass1-
dc.identifier.bibliographicCitationScientific Reports, v.13, no.1-
dc.citation.titleScientific Reports-
dc.citation.volume13-
dc.citation.number1-
dc.description.isOpenAccessY-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.identifier.wosid001034058100033-
dc.relation.journalWebOfScienceCategoryMultidisciplinary Sciences-
dc.relation.journalResearchAreaScience & Technology - Other Topics-
dc.type.docTypeArticle-
dc.subject.keywordPlusALZHEIMERS-DISEASE-
dc.subject.keywordPlusNEUROTROPHIC FACTOR-
dc.subject.keywordPlusINHIBITORY-ACTIVITY-
dc.subject.keywordPlusCHOLINERGIC SYSTEM-
dc.subject.keywordPlusLOCOMOTOR-ACTIVITY-
dc.subject.keywordPlusMESSENGER-RNA-
dc.subject.keywordPlusIN-VITRO-
dc.subject.keywordPlusRESVERATROL-
dc.subject.keywordPlusCONSTITUENTS-
dc.subject.keywordPlusDERIVATIVES-
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