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dc.contributor.authorSang, Mingyu-
dc.contributor.authorCho, Myeongki-
dc.contributor.authorLim, Selin-
dc.contributor.authorMin, In Sik-
dc.contributor.authorHan, Yuna-
dc.contributor.authorLee, Chanwoo-
dc.contributor.authorShin, Jongwoon-
dc.contributor.authorYoon, Kukro-
dc.contributor.authorYeo, Woon-Hong-
dc.contributor.authorLee, Taeyoon-
dc.contributor.authorWon, Sang Min-
dc.contributor.authorJung, Youngmee-
dc.contributor.authorHeo, Yun Jung-
dc.contributor.authorYu, Ki Jun-
dc.date.accessioned2024-01-19T09:30:40Z-
dc.date.available2024-01-19T09:30:40Z-
dc.date.created2023-07-20-
dc.date.issued2023-06-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/113638-
dc.description.abstractContinuous glucose monitoring (CGM) allows patients with diabetes to manage critical disease effectively and autonomously and prevent exacerbation. A painless, wireless, compact, and minimally invasive device that can provide CGM is essential for monitoring the health conditions of freely moving patients with diabetes. Here, we propose a glucose-responsive fluorescence-based highly sensitive biodegradable microneedle CGM system. These ultrathin and ultralight microneedle sensor arrays continuously and precisely monitored glucose concen-tration in the interstitial fluid with minimally invasive, pain-free, wound-free, and skin inflammation-free out-comes at various locations and thicknesses of the skin. Bioresorbability in the body without a need for device removal after use was a key characteristic of the microneedle glucose sensor. We demonstrated the potential long-term use of the bioresorbable device by applying the tether-free CGM system, thus confirming the success-ful detection of glucose levels based on changes in fluorescence intensity. In addition, this microneedle glucose sensor with a user-friendly designed home diagnosis system using mobile applications and portable accessories offers an advance in CGM and its applicability to other bioresorbable, wearable, and implantable monitoring device technology.-
dc.languageEnglish-
dc.publisherAmerican Association for the Advancement of Science-
dc.titleFluorescent-based biodegradable microneedle sensor array for tether-free continuous glucose monitoring with smartphone application-
dc.typeArticle-
dc.identifier.doi10.1126/sciadv.adh1765-
dc.description.journalClass1-
dc.identifier.bibliographicCitationScience Advances, v.9, no.22-
dc.citation.titleScience Advances-
dc.citation.volume9-
dc.citation.number22-
dc.description.isOpenAccessY-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.identifier.wosid001009737900021-
dc.identifier.scopusid2-s2.0-85160751720-
dc.relation.journalWebOfScienceCategoryMultidisciplinary Sciences-
dc.relation.journalResearchAreaScience & Technology - Other Topics-
dc.type.docTypeArticle-
dc.subject.keywordPlusDIABETES-MELLITUS-
dc.subject.keywordPlusPENETRATION-
dc.subject.keywordPlusFABRICATION-
dc.subject.keywordPlusRELEASE-
dc.subject.keywordPlusMICE-
dc.subject.keywordPlusSOFT-
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