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dc.contributor.authorYang, Suah-
dc.contributor.authorSun, In-Cheol-
dc.contributor.authorHwang, Hee Sook-
dc.contributor.authorShim, Man Kyu-
dc.contributor.authorYoon, Hong Yeol-
dc.contributor.authorKim, Kwangmeyung-
dc.date.accessioned2024-01-19T14:33:32Z-
dc.date.available2024-01-19T14:33:32Z-
dc.date.created2021-09-05-
dc.date.issued2021-05-21-
dc.identifier.issn2050-7518-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/116981-
dc.description.abstractImmunogenic cell death (ICD) occurring by chemical and physical stimuli has shown the potential to activate an adaptive immune response in the immune-competent living body through the release of danger-associated molecular patterns (DAMPs) into the tumor microenvironment (TME). However, limitations to the long-term immune responses and systemic toxicity of conventional ICD inducers have led to unsatisfactory therapeutic efficacy in ICD-based cancer immunotherapy. Until now, various nanoparticle-based ICD-inducers have been developed to induce an antitumor immune response without severe toxicity, and to efficiently elicit an anticancer immune response against target cancer cells. In this review, we introduce a recent advance in the designs and applications of nanoparticle-based therapeutics to elicit ICD for effective cancer immunotherapy. In particular, combination strategies of nanoparticle-based ICD inducers with typical theranostic modalities are introduced intensively. Subsequently, we discuss the expected challenges and future direction of nanoparticle-based ICD inducers to provide strategies for boosting ICD in cancer immunotherapy. These versatile designs and applications of nanoparticle-based therapeutics for ICD can provide advantages to improve the therapeutic efficacy of cancer immunotherapy.-
dc.languageEnglish-
dc.publisherROYAL SOC CHEMISTRY-
dc.titleRediscovery of nanoparticle-based therapeutics: boosting immunogenic cell death for potential application in cancer immunotherapy-
dc.typeArticle-
dc.identifier.doi10.1039/d1tb00397f-
dc.description.journalClass1-
dc.identifier.bibliographicCitationJOURNAL OF MATERIALS CHEMISTRY B, v.9, no.19, pp.3983 - 4001-
dc.citation.titleJOURNAL OF MATERIALS CHEMISTRY B-
dc.citation.volume9-
dc.citation.number19-
dc.citation.startPage3983-
dc.citation.endPage4001-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.identifier.wosid000644975000001-
dc.identifier.scopusid2-s2.0-85106620109-
dc.relation.journalWebOfScienceCategoryMaterials Science, Biomaterials-
dc.relation.journalResearchAreaMaterials Science-
dc.type.docTypeReview-
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KIST Article > 2021
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