Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Kim, Baeksun | - |
dc.contributor.author | Im, Heh-In | - |
dc.date.accessioned | 2024-01-19T14:34:09Z | - |
dc.date.available | 2024-01-19T14:34:09Z | - |
dc.date.created | 2022-01-25 | - |
dc.date.issued | 2021-05 | - |
dc.identifier.issn | 1355-6215 | - |
dc.identifier.uri | https://pubs.kist.re.kr/handle/201004/117018 | - |
dc.description.abstract | Nicotine can diversely affect neural activity and motor learning in animals. However, the impact of chronic nicotine on striatal activity in vivo and motor learning at long-term sparse timescale remains unknown. Here, we demonstrate that chronic nicotine persistently suppresses the activity of striatal fast-spiking parvalbumin interneurons, which mediate nicotine-induced deficit in sparse motor learning. Six weeks of longitudinal in vivo single-unit recording revealed that mice show reduced activity of fast-spiking interneurons in the dorsal striatum during chronic nicotine exposure and withdrawal. The reduced firing of fast-spiking interneurons was accompanied by spike broadening, diminished striatal delta oscillation power, and reduced sample entropy in local field potential. In addition, chronic nicotine withdrawal impaired motor learning with a weekly sparse training regimen but did not affect general locomotion and anxiety-like behavior. Lastly, the excitatory DREADD hM3Dq-mediated activation of striatal fast-spiking parvalbumin interneurons reversed the chronic nicotine withdrawal-induced deficit in sparse motor learning. Taken together, we identified that chronic nicotine withdrawal impairs sparse motor learning via disruption of activity in striatal fast-spiking parvalbumin interneurons. These findings suggest that sparse motor learning paradigm can reveal the subtle effect of nicotine withdrawal on motor function and that striatal fast-spiking parvalbumin interneurons are a neural substrate of nicotine's effect on motor learning. | - |
dc.language | English | - |
dc.publisher | Taylor & Francis | - |
dc.title | Chronic nicotine impairs sparse motor learning via striatal fast-spiking parvalbumin interneurons | - |
dc.type | Article | - |
dc.identifier.doi | 10.1111/adb.12956 | - |
dc.description.journalClass | 1 | - |
dc.identifier.bibliographicCitation | Addiction Biology, v.26, no.3 | - |
dc.citation.title | Addiction Biology | - |
dc.citation.volume | 26 | - |
dc.citation.number | 3 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.identifier.wosid | 000556212400001 | - |
dc.identifier.scopusid | 2-s2.0-85089098451 | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Substance Abuse | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Substance Abuse | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | ANXIETY-LIKE BEHAVIOR | - |
dc.subject.keywordPlus | DORSAL STRIATUM | - |
dc.subject.keywordPlus | CHOLINERGIC INTERNEURONS | - |
dc.subject.keywordPlus | PERFORMANCE IMPROVEMENT | - |
dc.subject.keywordPlus | DIFFERENTIAL REGULATION | - |
dc.subject.keywordPlus | SYNAPTIC PLASTICITY | - |
dc.subject.keywordPlus | NEURAL INFORMATION | - |
dc.subject.keywordPlus | DOPAMINE RELEASE | - |
dc.subject.keywordPlus | SEX-DIFFERENCES | - |
dc.subject.keywordPlus | SPATIAL MEMORY | - |
dc.subject.keywordAuthor | local field potential | - |
dc.subject.keywordAuthor | motor learning | - |
dc.subject.keywordAuthor | nicotine withdrawal | - |
dc.subject.keywordAuthor | dorsal striatum | - |
dc.subject.keywordAuthor | extracellular single-unit recording | - |
dc.subject.keywordAuthor | fast-spiking interneurons | - |
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