Chronic nicotine impairs sparse motor learning via striatal fast-spiking parvalbumin interneurons
- Authors
- Kim, Baeksun; Im, Heh-In
- Issue Date
- 2021-05
- Publisher
- Taylor & Francis
- Citation
- Addiction Biology, v.26, no.3
- Abstract
- Nicotine can diversely affect neural activity and motor learning in animals. However, the impact of chronic nicotine on striatal activity in vivo and motor learning at long-term sparse timescale remains unknown. Here, we demonstrate that chronic nicotine persistently suppresses the activity of striatal fast-spiking parvalbumin interneurons, which mediate nicotine-induced deficit in sparse motor learning. Six weeks of longitudinal in vivo single-unit recording revealed that mice show reduced activity of fast-spiking interneurons in the dorsal striatum during chronic nicotine exposure and withdrawal. The reduced firing of fast-spiking interneurons was accompanied by spike broadening, diminished striatal delta oscillation power, and reduced sample entropy in local field potential. In addition, chronic nicotine withdrawal impaired motor learning with a weekly sparse training regimen but did not affect general locomotion and anxiety-like behavior. Lastly, the excitatory DREADD hM3Dq-mediated activation of striatal fast-spiking parvalbumin interneurons reversed the chronic nicotine withdrawal-induced deficit in sparse motor learning. Taken together, we identified that chronic nicotine withdrawal impairs sparse motor learning via disruption of activity in striatal fast-spiking parvalbumin interneurons. These findings suggest that sparse motor learning paradigm can reveal the subtle effect of nicotine withdrawal on motor function and that striatal fast-spiking parvalbumin interneurons are a neural substrate of nicotine's effect on motor learning.
- Keywords
- ANXIETY-LIKE BEHAVIOR; DORSAL STRIATUM; CHOLINERGIC INTERNEURONS; PERFORMANCE IMPROVEMENT; DIFFERENTIAL REGULATION; SYNAPTIC PLASTICITY; NEURAL INFORMATION; DOPAMINE RELEASE; SEX-DIFFERENCES; SPATIAL MEMORY; local field potential; motor learning; nicotine withdrawal; dorsal striatum; extracellular single-unit recording; fast-spiking interneurons
- ISSN
- 1355-6215
- URI
- https://pubs.kist.re.kr/handle/201004/117018
- DOI
- 10.1111/adb.12956
- Appears in Collections:
- KIST Article > 2021
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