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dc.contributor.authorPark, Ji Hye-
dc.contributor.authorSon, Yang Ju-
dc.contributor.authorLee, Chang Ho-
dc.contributor.authorNho, Chu Won-
dc.contributor.authorYoo, Gyhye-
dc.date.accessioned2024-01-19T17:34:13Z-
dc.date.available2024-01-19T17:34:13Z-
dc.date.created2021-09-04-
dc.date.issued2020-04-22-
dc.identifier.issn2662-7671-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/118716-
dc.description.abstractBackground: Circaea mollis Sieb. & Zucc. has been used as a traditional herbal medicine in Hani Ethnopharmacy and possesses anti-arthritic activities. This study aimed to investigate the effect of Circaea mollis Siebold & Zucc on postmenopausal osteoporosis. Methods: For in vitro study, MCF7 breast cancer cells and MC3T3-E1 pre-osteoblast cells were utilized to estimate estrogenic and osteogenic activity. Osteoblastic markers were measured by western blot and real-time PCR. For in vivo study, female mature C57BL/6 mice were ovariectomized and oral administrated with 10 mg/kg and 40 mg/kg of EECM respectively. Results: EtOH extract of Circaea mollis Siebold & Zucc. (EECM) increased alkaline phosphatase activity and osteoblast marker levels at day 7 during differentiation of mouse preosteoblasts. EECM reduced osteoclast differentiation and bone resorption in an osteoblast-osteoclast primary co-culture system. In ovariectomized mice, EECM prevented the decrease in bone mineral density and recovered OSX and Runx2 via BMP2/4, Smad1/5/9 and p38. Conclusions: The results suggest that EECM may be effective in preventing bone loss, offering a promising alternative for the nutritional management of postmenopausal osteoporosis.-
dc.languageEnglish-
dc.publisherBMC-
dc.subjectESTROGEN-RECEPTOR-ALPHA-
dc.subjectDIFFERENTIATION-
dc.subjectOSTEOBLAST-
dc.subjectEXPRESSION-
dc.subjectCELLS-
dc.subjectOSTEOCLASTS-
dc.subjectPREVENTION-
dc.subjectMECHANISMS-
dc.subjectINDUCTION-
dc.titleCircaea mollis Siebold & Zucc. Alleviates postmenopausal osteoporosis in a mouse model via the BMP-2/4/Runx2 pathway-
dc.typeArticle-
dc.identifier.doi10.1186/s12906-020-02914-7-
dc.description.journalClass1-
dc.identifier.bibliographicCitationBMC COMPLEMENTARY MEDICINE AND THERAPIES, v.20, no.1-
dc.citation.titleBMC COMPLEMENTARY MEDICINE AND THERAPIES-
dc.citation.volume20-
dc.citation.number1-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.identifier.wosid000550305300001-
dc.identifier.scopusid2-s2.0-85084268518-
dc.relation.journalWebOfScienceCategoryIntegrative & Complementary Medicine-
dc.relation.journalResearchAreaIntegrative & Complementary Medicine-
dc.type.docTypeArticle-
dc.subject.keywordPlusESTROGEN-RECEPTOR-ALPHA-
dc.subject.keywordPlusDIFFERENTIATION-
dc.subject.keywordPlusOSTEOBLAST-
dc.subject.keywordPlusEXPRESSION-
dc.subject.keywordPlusCELLS-
dc.subject.keywordPlusOSTEOCLASTS-
dc.subject.keywordPlusPREVENTION-
dc.subject.keywordPlusMECHANISMS-
dc.subject.keywordPlusINDUCTION-
dc.subject.keywordAuthorCircaea mollis Siebold & Zucc-
dc.subject.keywordAuthorPostmenopausal osteoporosis-
dc.subject.keywordAuthorOsteoblast differentiation-
dc.subject.keywordAuthorRunt-related transcription factor 2-
dc.subject.keywordAuthorBone morphogenetic protein 2/4-
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