DSpace at KISTKIST Article2019

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dc.contributor.authorAslam, Adil S.-
dc.contributor.authorFuwad, Ahmed-
dc.contributor.authorRyu, Hyunil-
dc.contributor.authorSelvaraj, Baskar-
dc.contributor.authorSong, Jae-Won-
dc.contributor.authorKim, Dae Won-
dc.contributor.authorKim, Sun Min-
dc.contributor.authorLee, Jae Wook-
dc.contributor.authorJeon, Tae-Joon-
dc.contributor.authorCho, Dong-Gyu-
dc.date.accessioned2024-01-19T19:02:35Z-
dc.date.available2024-01-19T19:02:35Z-
dc.date.created2022-01-10-
dc.date.issued2019-10-04-
dc.identifier.issn1523-7060-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/119467-
dc.description.abstractCl--ion transporters (2a-2h) were synthesized based on the binding motifs of prodigiosin. Transporter 2e clearly displays Cl--ion transportation activity across both model and live cell membranes. Furthermore, 2e can disrupt Ca2+ homeostasis and increase the intracellular concentration of Ca2+ in the DLD-1 cell. This disruption can lead to Caspase-dependent apoptosis supported by CHOP expression (a marker of ER stress) and the appearance of the cleaved forms of Caspase 3 and PARP.-
dc.languageEnglish-
dc.publisherAMER CHEMICAL SOC-
dc.subjectCELL-DEATH-
dc.subjectAPOPTOSIS-
dc.subjectBINDING-
dc.subjectCALCIUM-
dc.titleSynthetic Anion Transporters as Endoplasmic Reticulum (ER) Stress Inducers-
dc.typeArticle-
dc.identifier.doi10.1021/acs.orglett.9b02823-
dc.description.journalClass1-
dc.identifier.bibliographicCitationORGANIC LETTERS, v.21, no.19, pp.7828 - 7832-
dc.citation.titleORGANIC LETTERS-
dc.citation.volume21-
dc.citation.number19-
dc.citation.startPage7828-
dc.citation.endPage7832-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.identifier.wosid000489200100031-
dc.identifier.scopusid2-s2.0-85072656803-
dc.relation.journalWebOfScienceCategoryChemistry, Organic-
dc.relation.journalResearchAreaChemistry-
dc.type.docTypeArticle-
dc.subject.keywordPlusCELL-DEATH-
dc.subject.keywordPlusAPOPTOSIS-
dc.subject.keywordPlusBINDING-
dc.subject.keywordPlusCALCIUM-
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KIST Article > 2019
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