Xylodon flaviporus-Derived Drimane Sesquiterpenoids That Inhibit Osteoclast Differentiation

Authors
Kwon, JaeyoungLee, HyaeminRyu, Seung MokJang, YeongseonKwon, Hak CheolGuo, YuanqiangKang, Jong SoonKim, Jae-JinLee, Dongho
Issue Date
2019-10
Publisher
American Chemical Society
Citation
Journal of Natural Products, v.82, no.10, pp.2835 - 2841
Abstract
The presence of excessive osteoclasts is a major factor in skeletal diseases. The present study aimed to discover osteoclast differentiation inhibitors from the basidiomycete Xylodon flaviporus. Seven new drimane sesquiterpenoids (1-7) and 7-ketoisodrimenin-5-ene (8) were obtained and characterized by various spectroscopic methods. The isolated compounds were evaluated for their inhibitory effects against receptor activator of nuclear factor-kappa-B ligand-induced osteoclastogenesis in mouse bone marrow macrophages. Compounds 1, 3, and 6 showed potent activities with IC50 values of 1.6, 0.9, and 2.1 mu M, respectively, while 4, 5, and 7 exhibited relatively weak activities with IC50 values of 10.7, 10.1, and 8.5 mu M, respectively.
ISSN
0163-3864
URI
https://pubs.kist.re.kr/handle/201004/119530
DOI
10.1021/acs.jnatprod.9b00559
Appears in Collections:
KIST Article > 2019
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