Activatable NIRF/MRI dual imaging probe using bio-inspired coating of glycol chitosan on superparamagnetic iron oxide nanoparticles
- Authors
- Chung, In Jae; Jeon, Seong Ik; Cha, Eui-Joon; Byun, Youngro; Kwon, Ick Chan; Kim, Young Il; Kim, Kwangmeyung; Ahn, Cheol-Hee
- Issue Date
- 2019-08
- Publisher
- 한국공업화학회
- Citation
- Journal of Industrial and Engineering Chemistry, v.76, pp.403 - 409
- Abstract
- MRI and NIRF multimodal imaging probe was fabricated and investigated. Glycol chitosan coated SPION was decorated by MMP-2 substrate conjugating BHQ-3 and Cy5.5 dye at each end (BCMG-SPION). NIRF signals were recovered in the presence of MMP-2 at a sub-nanomolar level. BCMG-SPION produced the maximum NIRF intensity at 48 h post injection in vivo. Evaluation of the BCMG-SPION in the tumor tissue by MRI showed that relative contrast enhancement was 34% higher than normal muscles. NIRF images of excised organs showed the highest NIRF signal in tumor and the intensity was at least 8 times higher than other organs. (C) 2019 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved.
- Keywords
- FLUORESCENT NANOPARTICLES; NANOCRYSTALS; SYSTEM; ACID; In vivo dual imaging; MRI; Optical imaging; Bio-inspired adhesion; Iron oxide; Nanoparticles
- ISSN
- 1226-086X
- URI
- https://pubs.kist.re.kr/handle/201004/119718
- DOI
- 10.1016/j.jiec.2019.04.006
- Appears in Collections:
- KIST Article > 2019
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