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dc.contributor.authorKim, Hyo Young-
dc.contributor.authorKang, Seong Jae-
dc.contributor.authorJeon, Yongmoon-
dc.contributor.authorAn, Jinsu-
dc.contributor.authorPark, Jihyun-
dc.contributor.authorLee, Hee Jae-
dc.contributor.authorJang, Jeong-Eun-
dc.contributor.authorAhn, JongSeong-
dc.contributor.authorBang, Duhee-
dc.contributor.authorChung, Hak Suk-
dc.contributor.authorJeong, Cherlhyun-
dc.contributor.authorAhn, Dae-Ro-
dc.date.accessioned2024-01-19T20:33:25Z-
dc.date.available2024-01-19T20:33:25Z-
dc.date.created2021-09-02-
dc.date.issued2019-03-
dc.identifier.issn1359-7345-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/120291-
dc.description.abstractWe demonstrated that 19 out of 20 RNA residues in the guide region of crRNA can be replaced with DNA residues with high GC-contents. The cellular activity of the chimeric crRNAs to disrupt the target gene was comparable to that of the native crRNA.-
dc.languageEnglish-
dc.publisherROYAL SOC CHEMISTRY-
dc.titleChimeric crRNAs with 19 DNA residues in the guide region show the retained DNA cleavage activity of Cas9 with potential to improve the specificity-
dc.typeArticle-
dc.identifier.doi10.1039/c8cc08468h-
dc.description.journalClass1-
dc.identifier.bibliographicCitationCHEMICAL COMMUNICATIONS, v.55, no.24, pp.3552 - 3555-
dc.citation.titleCHEMICAL COMMUNICATIONS-
dc.citation.volume55-
dc.citation.number24-
dc.citation.startPage3552-
dc.citation.endPage3555-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.identifier.wosid000462654300025-
dc.identifier.scopusid2-s2.0-85063077532-
dc.relation.journalWebOfScienceCategoryChemistry, Multidisciplinary-
dc.relation.journalResearchAreaChemistry-
dc.type.docTypeArticle-
dc.subject.keywordPlusCRISPR-
dc.subject.keywordPlusRNA-
dc.subject.keywordPlusENDONUCLEASE-
dc.subject.keywordPlusMUTATIONS-
dc.subject.keywordPlusNUCLEASES-
dc.subject.keywordPlusSYSTEM-
dc.subject.keywordAuthorCRISPR-
dc.subject.keywordAuthorCas9-
dc.subject.keywordAuthorChimeric crRNA-
dc.subject.keywordAuthortarget specificity-
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