Double-pulse laser illumination method for measuring fast cerebral blood flow velocities in the deep brain using a fiber-bundle-based endomicroscopy system

Authors
Kim, MinkyungJinki HongShin, Hyun-Joon
Issue Date
2018-06
Publisher
The Optical Society
Citation
Biomedical Optics Express, v.9, no.6, pp.2699 - 2715
Abstract
We present a new fiber-bundle-based endomicroscopy system to measure the fast cerebral blood flow (CBF) velocity in blood vessels located between the surface and the deep brain of living animals. The CBF velocity is obtained by measuring the displacement of the partially overlapped red blood cell images directly, using double-pulse 532-nm laser illumination. The proposed method could measure CBF in blood vessels with diameters ranging from 4 mu m to 42 mu m and could measure CBF velocities up to 3.2 mu m/ms for different vessel diameters at a depth of 2.1 mm from the brain surface in a living mouse. (C) 2018 Optical Society of America under the terms of the OSA Open Access Publishing Agreement
Keywords
PARTICLE IMAGE VELOCIMETRY; IN-VIVO; ALZHEIMERS-DISEASE; CAPILLARIES; MICROSCOPE; PIV; MICROCIRCULATION; MICROVESSELS; STIMULATION; METABOLISM; fiber optics imaging; integrated optics; blood monitoring; endoscopic imaging; fluorescence microscopy
ISSN
2156-7085
URI
https://pubs.kist.re.kr/handle/201004/121331
DOI
10.1364/BOE.9.002699
Appears in Collections:
KIST Article > 2018
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